Synthesis of Biomimetic Hydroxyapatite in Syntetic Body Fluids


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In this study, biomemitic hydroxyapatite was prepared as a nano-sized powder from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts, but using the different contents of PVP modified hydroxyapatite and synthetic body fluid (SBF) solutions as synthesis medium instead of pure water at 37.4C and pH of 7.4. SBF was prepared in accord with the chemical analysis of human body fluid, with ion concentrations nearly equal to those of the inorganic constituents of human blood plasma. Characterization and chemical analaysis of the synthesized biomemitic hydroxyapatite powders and pure hydroxyapatite were investigated by X-ray powder diffraction, scanning electron microscopy, and inductively coupled plasma atomic emission spectroscopy. Rheological properties of HAP sol which reflected the interaction of hydroxyapatite particles were measured by R/S rheometer. The results showed that PVP evidently affected the stability and rheological properties of HAP sol, and PVP were based on the different mechanism at different concentrations. PVP was operating as an interparticle bridging reagent at low concentrations(0.5%), while it acted as an dispersant at high concentrations(2.0%). The biomemitic hydroxyapatite with the sizes of 10~30nm was spherical and poor crystalline, which was synthesized in synthetic body fluid (SBF) by addition of 2.0% PVP.



Key Engineering Materials (Volumes 368-372)

Edited by:

Wei Pan and Jianghong Gong




Z. Y. Yin et al., "Synthesis of Biomimetic Hydroxyapatite in Syntetic Body Fluids", Key Engineering Materials, Vols. 368-372, pp. 1169-1171, 2008

Online since:

February 2008




[1] H. Aoki: Journal of Materials Science: Material in Medicine. Vol. 11(2000), p.67.

[2] J.D. Chen, Y.J. Wang, K. Wei, et al: Biomaterials. Vol. 28(2007), p.2275.

[3] C.Y. Ning, Y.J. Wang, X.F. Chen , et al: Surface and Coatings Technology, Vol. 200(2005), p.2403.

[4] C.Y. Ning: Journal of Wuhan University of Technology-Materials Science, Vol. 20[S1](2007), p.56.

[5] K.Y. Tan, X.F. Chen and Y.J. Wang: Materials Review. Vol. 20(2006), p.144.

[6] H. Wang and Y.F. Wang: Scientific Experiment. Vol. 6(2005), p.3.

[7] K. Wei, Y.J. Wang, C. Lai, et al.: Materials Letters, Vol. 59(2005), p.220.

[8] Z.D. Wang, Z.L. Xu, Y.G. Yang, et al.: Materials Review. Vol. 20(2006), p.53.

[9] G.D. Wei, C.W. Nan and D.P. Yu: Tsinghua Science and Technology. Vol. 10(2005), p.736.

[10] X. Gu, C. Nie, Y. Lai, et al.: Materials Chemistry and Physics. Vol. 96(2006), p.217.

[11] X. Sui,Y. Liu,C. Shao, et al.: Chemical Physics Letters. Vol. 424(2006), p.340.

[12] J.X. Liu, F. Shi., J. Zhou, et al.: journal of the Chinese Ceramic Society. Vol. 34(2006), p.334.

[13] F. Wang, M.S. Li, Y.P. Lu, et al.: Transactions of Materids and Heat Treatment. Vol. 26(2005), p.8.

[14] Y.J. Wang, C.R. Yang, H.D. Zheng, et al.: Key Engineering Materials. Vol. 330-332 (2007), p.671.

[15] D.C.H. Cheng: Int J Cosmet Sci. Vol. 9(1987), p.151.

[16] Z. Zheng: Introduction to Colloid Science(Higher Education Press, Beijing, China, 1989), p.401.