Preparation of Porous Polycaprolactone Scaffolds by Using Freeze-Drying Combined Porogen-Leaching Methods


Article Preview

The microstructure of scaffold was one of key factors for tissue engineering. Porous polycaprolactone (PCL) scaffolds were fabricated by combination of porogen-leaching and freeze-drying process. Ice particulates were used as porogen material, and PCL solutions in chloroform were mixed with ice particulates for 5minuture at zero temperature. Then the mixture was freezed in liquid nitrogen, and porous scaffold was prepared by freeze - drying finally. The microstructure and properties of the scaffolds were investigated. Porous structure of the scaffolds showed that good 3D microstructure and no porogen remained in the scaffold; pore size and porosity were determined by the size and mass fraction of ice particulates. The results demonstrated that the Scaffolds possessed open and interconnected pores with sizes ranging from several μm to more than 300μm and porosities of 50~80%.



Key Engineering Materials (Volumes 368-372)

Edited by:

Wei Pan and Jianghong Gong




C. Y. Ning et al., "Preparation of Porous Polycaprolactone Scaffolds by Using Freeze-Drying Combined Porogen-Leaching Methods", Key Engineering Materials, Vols. 368-372, pp. 1224-1226, 2008

Online since:

February 2008




[1] P. Langer and J.P. Vacanti: Science. Vol. 260(1993), p.920.

[2] N. Zhao, Y. Wang, X. Chen, et al.: Key Engineering Materials. Vol. 330-332(2007), p.919.

[3] S. H. Oha, K. Park, J. M. Kimb, et al.: Biomaterials. Vol. 28(2007), p.1664.

[4] Y.S. Nam, J.J. Yoon and T.G. Park: J. Biomedical Mater. Res. (Appl Biomater). Vol. 53(2000), p.1.

[5] T. Kim, J. Yoon, D. Lee, et al.: Biomaterials. Vol. 27(2006), p.152.

[6] K. Whang, C. Thomas and K. Healy: Polymer. Vol. 36(1995), p.837.

[7] J.D. Chen, Y.J. Wang, K. Wei, et al.: Biomaterials. Vol. 28(2007), p.2275.

[8] C.Y. Ning: J. Wuhan Uni. Technol. -Materials Science. Vol. 20[S1](2007), p.56.

[9] J.H. Brauker, V. Carr-Brendel, L.A. Martinson, et al.: J Biomed Mater Res. Vol. 29(1995), p.1517.

[10] J. Klawitter and S. Hulbert: J Biomed Mater Res Symp. Vol. 2(1971), p.161.

[11] K. Whang, K.E. Healy, D.R. Elenz, et al.: Tissue Eng. Vol. 5(1999), p.35.

[12] L.D. Zardiackas, D.E. Parsell, L.D. Dillon, et al.: J Biomed Mater Res. Vol. 58(2001), p.180.