Silica-Based Ordered Mesoporous Materials for Biomedical Applications


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Much research effort has been committed to the development of bioceramics that promote bone tissue regeneration and this is still one of the greatest challenges for the scientific community. In this sense, silica-based ordered mesoporous materials constitute a new generation of bioceramics that combine the intrinsic properties of bioceramics, such as bioactive behavior, together with the capability to host and controlled release biologically active molecules that promote new bone formation, i.e. drug delivery systems. In this chapter, the recent advances aimed at tailoring ordered mesoporous materials for biomedical applications will be tackled and critically discussed.



Edited by:

Maria Vallet-Regí






I. Izquierdo-Barba et al., "Silica-Based Ordered Mesoporous Materials for Biomedical Applications", Key Engineering Materials, Vol. 377, pp. 133-150, 2008

Online since:

March 2008




[1] M. Vallet-Regí: J. Chem. Soc. Dalton Trans. Vol. 2 (2001), p.97.

[2] M. Vallet-Regí: Dalton Trans. (2006), p.5211.

[3] A. J. Salinas and M. Vallet-Regí: Z. Anorg. Allg. Chem (2007), p.1762.

[4] M. Vallet-Regí, Chem. Eng. J. (2007), doi: 10. 1016/j. cej. 2007. 10. 015.

[5] L.L. Hench, R.J. Splinter, W.C. Allen and T. K Greenlee: J. Biomed. Mater. Res. Vol. 2 (1971), p.117.

[6] L. L. Hench: J. Am Ceram. Soc. Vol. 74 (1991), p.1487.

[7] L. L. Hench: J. Am. Ceram,. Soc. Vol. 81 (1998), p.1705.

[8] M. Vallet-Regí, C.V. Ragel and A.J. Salinas: Eur. J. Inorg. Chem. (2003), p.1029.

[9] J.S. Beck, J.C. Vartuli, W.J. Roth, M.E. Leonowicz, C.T. Kresge, K.D. Schmitt, C.T.W. Chu, D.H. Olson, E.W. Sheppard, S. B McCullen, J.B. Higgings and J.L. Schelenker: J. Am. Chem. Soc. Vol. 114 (1992), p.10834.

DOI: 10.1021/ja00053a020

[10] C.T. Kresge, M.E. Leonowicz, W.J. Roth, J.C. Vartuli and J.S. Beck: Nature. Vol. 359 (1992), p.710.

[11] T. Yanagisawa, T. Shimizu, K. Kuroda and C. Kato: Bull. Chem. Soc Jpn. Vol. 63 (1990), p.988.

[12] D.Y. Zhao, J.L. Feng, Q.S. Huo, N. Melosh, G.H. Fredricksson, B.F. Chmelka and G.D. Stuky: Science. Vol. 279 (1998), p.548.

[13] M. Kaneda, T. Tsubakiyawa, A. Carlsson, l Y. Sakamoto, T. Oshuna, O. Terasaki, H. Joo and R. Ryoo: J. Phys. Chem. B Vol. 106 (2002), p.1256.

[14] Q.S. Huo, D.I. Margolese and G.D. Stucky: Chem. Mater. Vol. 8 (1996), p.1147.

[15] F. Hoffmann, M. Cornelius, J. Morell and M. Fröba: Angew. Chem. Int. Ed. Vol. 45 (2006), p.3216.

[16] M. Vallet-Regí, L. Ruiz-González, I. Izquierdo-Barba and J.M. González-Calbet: J. Mater. Chem. Vol. 16 (2006), p.26.

DOI: 10.1039/b509744d

[17] M. Vallet-Regí, A. Rámila, R.P. del Real and J.P. Pérez-Pariente: Chem. Mater. Vol. 13 (2001), p.308.

[18] A. López-Noriega, D. Arcos, I. Izquierdo-Barba, Y. Sakamoto, O. Terasaki and M. ValletRegí: Chem. Mater. Vol. 18 (2006), p.3137.

DOI: 10.1021/cm060488o

[19] R. Z. LeGeros and G. Daculsi, In: Handbook of bioactive ceramics: in vivo tranformation of bopahsic calcium phosphate ceramics: ultrastrcutural and physicochemistry characterization, edited by Yamamuro N, Hench LL, Wilson- Hench J. Vol. 2 of Calcium Phospahte ceramics, CRC Press Boca Raton (1990).

DOI: 10.1002/jbm.820250709

[20] IUPAC Manual of Symbols and Terminology, Appendix 2, Pt. 1, Colloid and Surface Chemistry: Pure Appl. Chem. Vol. 31 (1972), p.578.

[21] I. Izquierdo-Barba, L. Ruiz-Gonzalez, J. C. Doadrio and J. M. González-Calbet: Solid State Sci. Vol. 1 (2005), p.983.

DOI: 10.1016/j.solidstatesciences.2005.04.003

[22] X.X. Yan, C.Z. Yu, X.F. Zhou, J.W. Tang and D.Y. Zhao: Angew. Chem., Int. Ed. Vol. 43 (2004), p.5980.

[23] L.L. Hench and J. Wilson: Science Vol. 226 (1984), p.630.

[24] M. Vallet-Regí, D. Arcos and J. Pérez-Pariente: J. Biomed. Mater. Res. Vol. 51 (2000), p.23.

[25] M.M. Pereira, A.E. Clark and L.L. Hench: J. Biomed. Mater. Res. Vol. 28, (1994), p.693.

[26] M. Vallet-Regí: Chem. Eur. J. Vol. 12 (2006), p.5934.

[27] M. Vallet-Regíl, F. Balas, M. Colilla, M. Manzano: Solid State Sci. Vol. 9 (2007), p.768.

[28] M. Vallet-Regí, F. Balas and D. Arcos: Angew. Chem. Int. Ed. Vol. 46 (2007), p.2.

[29] M. Vallet-Regí, F. Balas, M. Colilla and M. Manzano, Drug Metab. Lett. Vol. 1 (2007) p.37.

[30] M. Vallet-Regí, J.C. Doadrio, A.L. Doadrio, I. Izquierdo-Barba and J. Pérez-Pariente: Solid State Ionics Vol. 172 (2004), p.435.

[31] A. L. Doadrio, E.M.B. Sousa, J.C. Doadrio, J. Pérez-Pariente, I. Izquierdo-Barba and M. Vallet-Regí: J. Control Release, Vol. 97 (2004), p.125.

DOI: 10.1016/j.jconrel.2004.03.005

[32] F. Qu, G. Zhu, S. Huang, S. Li, J. Sun, D. Zhang and S. Qui: Micro. Meso. Mater. Vol. 92, (2006) p.1.

[33] F. Balas, M. Manzano, P. Horcajada and M. Vallet-Regí: J. Am. Chem. Soc. Vol. 128 (2006), p.8116.

[34] J.C. Doadrio, E.M.B. Sousa, I. Izquierdo-Barba, A.L. Doadrio, J. Pérez-Pariente and M. ValletRegí: J. Mater. Chem. Vol. 16 (2006) p.462.

[35] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi and T. Yamamuro: J. Biomed. Mater. Res. Vol. 24 (1990), p.721.

[36] British Pharmacopoeia, British Pharmacopea Comission, London, Vol. II (1998) p. A315.

[37] S. Sugio, A. Kashima, S. Mochizuki, M. Noda and K. Kobayashi: Protein Eng. Vol. 12 (1999) p.439.

[38] Information on Protein Data Bank PDB ID#1ao6 (http: /www. rcsb. org/).

[39] S. W. Song, K. Hidajat and S. Kawi: Langmuir Vol. 21 (2005) p.9568.

[40] M. Vallet-Regí, F. Balas, M. Colilla and M. Manzano. Prog. Solid State Chem. (2007), doi: 10. 1016/j. progsolidstchem. 2007. 10. 002.

[41] P. Horcajada, A. Rámila, J. Pérez-Pariente and M. Vallet-Regí: Micropor. Mesopor. Mater. Vol 68 (2004), p.105.

[42] I. Izquierdo-Barba, A. Martínez, A.L. Doadrio, J. Pérez-Pariente and M. Vallet-Regí: Eur. J. Pharm. Sci. Vol. 26 (2005), p.365.

[43] C. Charnay, S. Bétu, C. Tourné-Péteilh, L. Nicole, D. Lerner and J. M. Devoisselle : Eur. J. Pharm. Biopharm., Vol. 57 (2004), p.533.

[44] T. Azaïs, C. Tourné-Péteilh, F. Aussenac, N. Baccile, C. Coelho, J. M. Devoisselle and F. Babonneau : Chem. Mater. Vol. 18 (2006), 6382.

DOI: 10.1021/cm061551c

[45] M. Manzano, V. Aina, C.O. Areán, F. Balas, V. Cauda, M. Colilla, M.R. Delgado and M. Vallet-Regí: Chem. Eng. J. (2007), doi: 10. 1016/j. cej. 2007. 07. 078.

[46] P. Horcajada, A. Rámila, G. Férey and M. Vallet-Regí: Solid State Sci. Vol. 8, (2006) p.1243.

[47] F. Balas, M. Manzano, M. Colilla and M. Vallet-Regí: Acta Biomaterialia. (2007) In Press.

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