Bone Regeneration at Cortical Bone Defect with Unidirectional Porous Hydroxyapatite In Vivo

Abstract:

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Unidirectional porous hydroxyapatite (UDPHAp) was developed which has microstructure in that cross sectionally oval pores 100 ~ 300µm in diameter penetrate through the material, and that is suitable for osteogenesis and angiogenesis.The porosity of the UDPHAp was 75 % and the compression strength was 14 MPa. A cortical bone defect was made at proximal tibia of Japanese white rabbit, and a trapezoidal prisms shaped UDPHAp was implanted. By histlogical evaluation, 2 weeks after implantation, new bone and new capillary was observed inside UDPHAp. Twelve weeks after implantation, new bone formation was observed in 41.6 % of the porous area. The results of this study suggest a great possibility of utilizing it in actual clinical setting as a bone substitution.

Info:

Periodical:

Key Engineering Materials (Volumes 396-398)

Main Theme:

Edited by:

Marcelo Prado and Cecília Zavaglia

Pages:

11-14

DOI:

10.4028/www.scientific.net/KEM.396-398.11

Citation:

M. Iwasashi et al., "Bone Regeneration at Cortical Bone Defect with Unidirectional Porous Hydroxyapatite In Vivo", Key Engineering Materials, Vols. 396-398, pp. 11-14, 2009

Online since:

October 2008

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Price:

$35.00

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