Fabrication of Encapsulated Silicagel Microsphere with Hydroxyapatite for Sustained-Release
Apatite nuclei were precipitated in the pores of silicagel microspheres by raising pH of simulated body fluid (SBF). By a soak in SBF, hydroxyapatite (HAp) was induced from the apatite nuclei and spread over whole surface area of the silicagel microspheres. Then encapsulated silicagel microspheres with HAp were fabricated.
Marcelo Prado and Cecília Zavaglia
S. Yamane et al., "Fabrication of Encapsulated Silicagel Microsphere with Hydroxyapatite for Sustained-Release", Key Engineering Materials, Vols. 396-398, pp. 519-522, 2009