Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling

Abstract:

Article Preview

Spherical porous calcium phosphate pellets were fabricated by high shear wet granulation using native starch as a binder. After a heat treatment to eliminate the organic template, pellets were loaded with ibuprofen by solvent evaporation method. In vitro drug release kinetics was determined using an USP II apparatus (Prolabo Dissolution Tester, France). Results showed the interest of the calcination and of the increase in the binder-porogen content, to improve the drug loading (higher drug content) and prolong the release of the drug substance.

Info:

Periodical:

Key Engineering Materials (Volumes 396-398)

Main Theme:

Edited by:

Marcelo Prado and Cecília Zavaglia

Pages:

535-538

DOI:

10.4028/www.scientific.net/KEM.396-398.535

Citation:

M. Viana et al., "Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling", Key Engineering Materials, Vols. 396-398, pp. 535-538, 2009

Online since:

October 2008

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.