A Novel Bone Scaffolds Based on Hyperbranched Polyglycerol Fibers Filled with Hydroxyapatite Nanoparticles: In Vitro Cell Response

Abstract:

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A novel bone scaffolding material was successfully fabricated by electrospinning from hyperbranched polyglycerol (HPGL) solutions containing nanoparticles of hydroxyapatite (HA). The potential use of the electrospun fibrous HPGL-HA scaffolds for bone regeneration was evaluated in vitro with human osteoblasts in terms of alkaline phosphatase (ALP) activity of the cells that were cultured directly on the scaffolds. The results were compared with those on corresponding HPLG-HA solution-cast film scaffolds. It was found that all of the fibrous scaffolds promoted much better adhesion and proliferation of cells than the corresponding film scaffolds.

Info:

Periodical:

Key Engineering Materials (Volumes 396-398)

Main Theme:

Edited by:

Marcelo Prado and Cecília Zavaglia

Pages:

633-636

DOI:

10.4028/www.scientific.net/KEM.396-398.633

Citation:

A. A. A. de Queiroz et al., "A Novel Bone Scaffolds Based on Hyperbranched Polyglycerol Fibers Filled with Hydroxyapatite Nanoparticles: In Vitro Cell Response", Key Engineering Materials, Vols. 396-398, pp. 633-636, 2009

Online since:

October 2008

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$35.00

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