Porous Alumina Scaffolds with Bioactive Coating: Implants in the Rat Tibia and In Vitro Studies
Ceramic scaffolds, mechanically qualified, highly porous, non biodegradable and with bioactive coating have been manufactured. The aim of this study was evaluated mechanical and in vivo responses of the porous alumina scaffolds with bioactive coating. The bioactive coating was performed under vacuum with bio-glass (45S5®)) and hydroxyapatite (HAp). Alumina ceramics (Al2O3) are used for bone implants in function of the biocompatibility and the high mechanical reliability of this material. Unfavourably alumina is a bioinert material and bone ingrowths are hard to occur and any implant anchorage becomes difficult. To improve this, ceramic scaffold samples were made with porosity concentration around 75vol% and with average pores diameters around 190.0µm. They were mechanically characterized through macro and micro structural analyses and mechanical tests and biologically through cell culture tests with fibroblastic VERO cell line for cytotoxicity and animal experiments on tibiae rats – Rattus norvegiicus albinos – aiming histological and line scan analysis in order to check the scaffold-bone cellular interaction. Current results seem to suggest the promising properties of the bioactive coated alumina ceramic scaffolds tested. The concentration of 75vol% alumina showed to be the great alternative for an economical solution for porous alumina ceramic scaffolds related to the mechanical properties and bone integration.
Marcelo Prado and Cecília Zavaglia
C. C. Camilo et al., "Porous Alumina Scaffolds with Bioactive Coating: Implants in the Rat Tibia and In Vitro Studies", Key Engineering Materials, Vols. 396-398, pp. 699-702, 2009