Preparation and Characterization of Porous Scaffolds Consisted of Hydroxyapatite, Polysaccharides and Collagen for Cartilage Tissue Engineering

Abstract:

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Porous scaffolds, consisted of hydroxyapatite (HAp), chondroitinsulfate (ChS) and collagen, were prepared by freeze-drying technique. HAp/ChS composite particles were incorporated into a collagen matrix. Scanning electron microscope (SEM) observations showed that the porous scaffolds involved interconnected pores whose size was 80~200 µm in diameter. The HAp/ChS particles were homogeneously distributed in the collagen matrix. Surface area of the scaffolds was increased by the incorporation of the particles. Compression tests in phosphate buffer saline indicated that the porous scaffolds had elastic property and had larger compressive modulus than the pure collagen scaffold. The porous scaffolds obtained in this study could be useful for a cartilage tissue engineering.

Info:

Periodical:

Key Engineering Materials (Volumes 396-398)

Main Theme:

Edited by:

Marcelo Prado and Cecília Zavaglia

Pages:

707-710

DOI:

10.4028/www.scientific.net/KEM.396-398.707

Citation:

T. Adegawa et al., "Preparation and Characterization of Porous Scaffolds Consisted of Hydroxyapatite, Polysaccharides and Collagen for Cartilage Tissue Engineering ", Key Engineering Materials, Vols. 396-398, pp. 707-710, 2009

Online since:

October 2008

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Price:

$35.00

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