Porous β-Tricalcium Phosphate Composite Scaffold Reinforced by K2HPO4 and Gelatin
To improve the mechanical strength of porous β-tricalcium phosphate (β-TCP) scaffold, porous β-TCP composite scaffold was prepared by immersing as-sintered porous β-TCP scaffold mixed with K2HPO4 in gelatin solution, following vacuum drying and glutaraldehyde cross-linking. The pattern of samples was characterized by X-ray diffraction (XRD). The surfaces of samples were analyzed by scanning electron microscopy (SEM). The compressive strength of samples was measured by universal test machine. The porosity percentage of samples was investigated by Archimedes method. The effects of time of samples incubating in simulated body fluid (SBF) on compressive strength and weight loss of samples were also studied. The results show that the compressive strength and water-retention rate of samples can be improved by the K2HPO4 and gelatin. The decrease rate of compressive strength and weight loss of samples is greater initially, and then slower compared with that of β-TCP scaffolds. When the samples incubate in SBF about 45d, the compressive strength and weight become increase, and finally are greater than that of β-TCP scaffold.
Wei Pan and Jianghong Gong
J. G. Ji et al., "Porous β-Tricalcium Phosphate Composite Scaffold Reinforced by K2HPO4 and Gelatin", Key Engineering Materials, Vols. 434-435, pp. 620-623, 2010