Biocompatibility and Medical Application of Carbon Material

Xu, Wen Feng

doi:10.4028/www.scientific.net/KEM.452-453.477

Paper Titles

Statistical Analysis of Seismic Vulnerability for Various Types of Building Structures in Wenchuan Earthquake
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Numerical Simulations on Shape Memory Effect of Shape Memory Polymer
p.465

A Model of Steel Frame for Simulating Connection Fractures
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Finite Element Fracture Mechanics Study of Web Connections with Tapered Beam Flange Plates
p.473

Biocompatibility and Medical Application of Carbon Material
p.477

Analysis on Coupling Damage of Liquid Rubber Based Concrete under Fatigue and Impact Loading
p.481

Analytical Solution of Elastic-Plastic Buckling of a Square Steel Tube Column under Axial Compressive Load and Bending Moment
p.485

Evolution of Aggregate Surface Characteristics in Polishing Process
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Effect of Friction on the Stress Field Strength of Gear Cracks
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HomeKey Engineering MaterialsAdvances in Fracture and Damage Mechanics IXBiocompatibility and Medical Application of Carbon...

Biocompatibility and Medical Application of Carbon Material

Abstract:

Carbon composites have good mechanical properties and preserve the inherent excellent biocompatibility of carbon, which make them great potential as orthopedic implants in human body. The present work reviews the biocompatible behavior and research situation of such materials for medical application. The mechanical properties, interface and surface modification problem of carbon composites are discussed in detail. Finally, the medical prospects and some problems needed to be solved of carbon composites are put forward.

Info:

Periodical:

Key Engineering Materials (Volumes 452-453)

Main Theme:

Advances in Fracture and Damage Mechanics IX

Edited by:

Akihide Saimoto and Prof. Ferri M.H.Aliabadi

Pages:

477-480

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.452-453.477

Citation:

W. F. Xu, "Biocompatibility and Medical Application of Carbon Material", Key Engineering Materials, Vols. 452-453, pp. 477-480, 2011

Online since:

November 2010

Authors:

Wen Feng Xu

Keywords:

Carbon Composites, Compatibility, Implant, Medical Application

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$41.00

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References

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[3] ZHANG Lei-Lei, LI He-Jun, LI Ke-Zhi, LI Xin-Tao, ZHAI Yan-Qiang, ZHANG Yu-Lei. Efect of Surface Roughness of Carbon／Carbon Composites on Osteoblast Growth Behaviour. Journal of Inorganic M aterial, 2008, 23(2 ): 342-345.

DOI: https://doi.org/10.3724/sp.j.1077.2008.00341

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[9] Xiong Xinbo, Li Hejun, Li Kezhi, Huang Jianfeng. The coatings of Calcium phosphate on carbonarbonarbon composites by a modified electrodeposition process, International Carbon Conference on Beijing, China, (2002).

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Paper TitlePages

The Study of Microstructure and Biocompatibility for Porous Polylactic Acid Scaffolds

Authors: Wen Feng Xu, Xiao Ling Liao

Abstract: The polylactic acids (PLA) scaffolds materials have been used to be the scaffolds materials of bone, cartilage gristle, blood vessel, nerve and skin due to its bioactivity, biocompatibility and biodegradable, today, the porous polylactic acid scaffolds had widely applied to tissue engineering. In the paper, the advance in study of microstructure and biocompatibility for this material were summarized. The lack in study of microstructure and compatibility has been pointed out and some viewpoints for further investigations are also made in this paper.

465

Biological Performances of Titanium Scaffolds: A Review

Authors: Kun Mediaswanti, Cui'e Wen, Elena P. Ivanova, Christopher C. Berndt, Francois Malherbe, James Wang

Abstract: Titanium and titanium alloys scaffolds have been widely explored in many load-bearing orthopaedic applications due to their excellent strength and corrosion resistance. However, their biocompatibility is also an important concern in these applications due to adverse reactions of metallic ions with the surrounding tissues after these metallic ions are released from implant surfaces. To respond on the challenge of producing a biocompatible material, a review on structural properties and surface treatments on titanium scaffolds and their effects on biological responses (in vitro and in vivo) are briefly presented.

1634

A Newly Developed Biocompatible Titanium Alloy and its Scaffolding by Powder Metallurgy

Authors: Cui'e Wen, Yun Cang Li

Abstract: Titanium and some of its alloys have received considerable attention for biomedical applications in recent years due to their excellent biocompatibility, high corrosion resistance and relatively low elastic modulus when compared to other metallic implant materials such as Co-Cr alloys and stainless steels. However, these alloys can still suffer from inadequate biocompatibility; lack of biological fixation and biomechanical mismatch with the properties of bone in vivo. In this study, a new biocompatible Ti alloy, Ti4Ta4Sn, consisting of alpha and beta phases was fabricated and their mechanical properties were investigated. Moreover, the Ti alloy was scaffolded into a porous structure using powder metallurgy with an architecture and elastic modulus mimicking those of cancellous bone. Cell culture results indicated that the new porous Ti alloy scaffold possesses excellent in vitro biocompatibility.

201

Nanoscale SiO₂/ZrO₂ Particulate-Reinforced Titanium Composites for Bone Implant Materials

Authors: Yun Cang Li, Chao Han, Xin Kun Zhu, Cui'e Wen, Peter D. Hodgson

Abstract: The mechanical property of porous pure titanium (Ti) scaffold with high porosity might become poorer than that of natural bone. In this study, new Ti-based biocompatible composites were developed to simultaneously meet the requirements of low elastic modulus and appropriate strength for implant materials when they are scaffolded into a porous structure. The nanoscale particulate-reinforced Ti-based composites with different concentrations of oxide particles such as SiO₂ and ZrO₂ were prepared using a powder metallurgical method. The strengths of the new nanoscale particulate-reinforced titanium composites were found to be significantly higher than that of pure Ti. Cell culture results revealed that the nanoscale particulate-reinforced titanium composites showed excellent biocompatibility and cell adhesion. Human SaOS₂ osteoblast-like cells grew and spread well on the surfaces of the new titanium composites. The nanoscale SiO₂ and ZrO₂ particulate-reinforced titanium composites are promising materials that have great potential for use as an orthopedic implant material.

242

Sintered Titanium-Hydroxyapatite Composites as Artificial Bones

Authors: Pongporn Moonchaleanporn, Nuchthana Poolthong, Ruangdaj Tongsri

Abstract: The design of engineered bone substitutes takes biocompatibility and mechanical compatibility into account as prerequisite requirements. Titanium (Ti) and hydroxyapatite (HA) with chemical formula of Ca₁₀(PO₄)₆(OH)₂, show good biocompatibility and are known as biomaterials. To combine metal powder (Ti) and ceramic powder (HA) as a composite material with mechanical properties comparable to those of natural bones needs strategy. In this work, powder metallurgy process was employed to produce Ti-HA composites, with nominal HA powder contents in the range of 0-100 vol.%. Mixtures of Ti and HA powders were pressed in a rigid die. Sintering was performed in vacuum atmosphere. The as-sintered specimens were tested on biocompatibility in a human-osteoblast cells. It was found that processing and materials parameters, including compaction pressure, control the composite microstructures and mechanical properties. Laboratory bone tissue culturing showed that a bone tissue could grow on the artificial bones (sintered Ti-HA composites).