Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers


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Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.



Edited by:

Osamu Hanaizumi and Masafumi Unno






T. M. Quynh et al., "Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers", Key Engineering Materials, Vol. 459, pp. 51-56, 2011

Online since:

December 2010




[1] G. Chen and A. S. Hoffman: Nature Vol. 373 (1995), p.49.

[2] B. H. Lee, B. West, R. McLemore, C. Pauken and B. L. Vermon: Biomacromolecules Vol. 7 (2006), p. (2059).

[3] F. Kohori, K. Sakai, T. Aoyagi, M. Yokoyama, Y. Sakurai and T. Okano: J. Control Release Vol. 55 (1998), p.87.

[4] G. Li, L. Guo, S. Ma and J. Liu: J. Polym. Sci. Part A: Polym. Chem. Vol. 47 (2009), p.1804.

[5] S. H. Kim, J. P. K. Tan, F. Nederberg, K. Fukushima, Y. Y. Yang, R. M. Waymouth and J. L. Hedrick: Macromolecules Vol. 42 (2009), p.25.

[6] C. L. Lo, K. M. Lin and G. H. Hsiue: J. Control Release Vol. 104 (2005), p.477.

[7] Y. Liu, J. Wu, L. Meng, L. Zhang and X. Lu: J. Biomed. Mater. Res. Part B: Applied Biomaterials Vol. 85B (2007), p.435.

[8] M. W. Dewirst, Springer Verlag, Berlin (1995), p.123.

[9] F. W. Florian, F. Nora and F. Holger: Macromolecules Vol. 42 (2009), p.5622.

[10] Y. Zhang, W. Yang, C. Wang, W. Wu and S. Fu, J. Nanosci. Nanotechnol. Vol. 6 (2006), p.1.

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