Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers

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Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.

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Periodical:

Edited by:

Osamu Hanaizumi and Masafumi Unno

Pages:

51-56

DOI:

10.4028/www.scientific.net/KEM.459.51

Citation:

T. M. Quynh et al., "Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers", Key Engineering Materials, Vol. 459, pp. 51-56, 2011

Online since:

December 2010

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$35.00

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