From a view point of engineering application, solid-liquid flow is one of the most practical phenomena, however MPS and other particle methods usually premises a constant size of all particles in the model. In a realistic phenomenon, the size of those particles is different. Koshizuka et al. has proposed new algorithm for solid-liquid flow simulation which is multi-scale DEM-MPS method. The method can calculate solid -liquid flow with a large difference of the particle scale. However, its program code requires a DEM part and a MPS part, and actual phenomenon includes various scales of particles. In order to analyze solid-liquid flow with different particles, modified Laplacian model and variable cut-off radius MPS method is proposed. This modification can directly deals with small particles and large particles. Calculation cost is kept and visualization of the results has more reality by these modifications.