A kind of 2-DOF parallel manipulator driven by two sliders moving along two parallel guides is analyzed. Based on the explicit expression of inverse position, velocity and acceleration analyses, the mobile trajectory of this manipulator is investigated and simulated. In trajectory planning, the trajectory profiles are assigned to be accelerated and decelerated at the first and last few seconds, respectively, and keep at constant speed for the remainder of time, where the forth-order polynomial is fitted during acceleration and deceleration, and clothoid curve is applied around the corner of axis. Then the mobile rule exerted on the actuator sliders is obtained using inverse position based on the desired end-effecter trajectory. Finally, the virtual prototype of this mechanism is modeled using Solidwork and the kinematics and dynamics simulation is performed using Cosmostion. The result shows that both velocity, acceleration of the sliders and the driving force exerted on the sliders are continuous curves, which can fully satisfy the demand of high-accuracy and real-time processing of the high-speed Manipulator.