Reconstruction of the Stomach with Smooth Muscle Cell Seeded Constructs in Rat Model

Abstract:

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We have developed a cell-seeded 3-dimension constructs tissue regeneration and used it successfully to repair defects of bone and cartilage. However, improvements of mechanical strength were demanded for clinical usage of reconstruction of gastrointestinal tracts. Rat model was used to evaluate whether PLGA constructs seeded with smooth muscle cells (SMC) could withstand suturing and anastomotic strength. Macrscopic, histological, and immunohistochemical assessment were performed to evaluate regeneration of stomach up to 14 days. SMC-seeded constructs show sufficient strength for suturing, no dehiscence, and better biocompatibility for clinical use, although further examination will be necessary to create a functional digestive tract.

Info:

Periodical:

Key Engineering Materials (Volumes 467-469)

Edited by:

Dehuai Zeng

Pages:

1876-1880

DOI:

10.4028/www.scientific.net/KEM.467-469.1876

Citation:

Y. X. Zheng et al., "Reconstruction of the Stomach with Smooth Muscle Cell Seeded Constructs in Rat Model", Key Engineering Materials, Vols. 467-469, pp. 1876-1880, 2011

Online since:

February 2011

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Price:

$35.00

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