The purpose of this study was to determine some physical and mechanical properties of sandwich panels manufactured from the core of Paulownia wood and surfaces of multilayer of fiberglass and resins. Paulownia was selected among Hardwoods because of its s low density (0.26 g/cm3) and high strength/weight ratio. Eight treatments were used for experiments: Two kinds of fiberglass (needle and combination of the needle and curtain type), two various resins (polyester and epoxy) and two core thicknesses (9mm and 19mm). Physical properties including density, resistance to water absorption, Dimensional stability, and Mechanical Properties such as internal bonding, compressive and bending strength of panels were measured following ASTM Standard. The results indicated that panels with 19 mm thick core had lower density (0.5g/ cm3) compared to the 9mm thick panels (0.7g/cm3). Bigger volume of wood in the core of panels with higher thickness was the main reason of this result. The experimental results showed that thickness of wood was effective on the modulus of rupture, modulus of elasticity, and compressive strength, significantly. Epoxy resin presented higher internal bond compared to the polyester resin. The two kind of fiberglass (needle one and the combination of needle and curtain type) didn’t have noticeable differences on mechanical properties. It also was found that Paulownia is a promising species for manufacturing sandwich panel.