Fabrication of Carbonate Apatite Block from Calcium Sulfate by Hydrothermal Treatment


Article Preview

Carbonate apatite (CO3Ap) is expected to be an ideal bone substitute since it can harmonize with the bone remodeling cycle. The aim of this study is to fabricate a CO3Ap bone substitute from gypsum (calcium sulfate, CaSO4·2H2O) hardening bodies based on dissolution-precipitation reaction. Calcium sulfate hemihydrate mixed with water at a water-to-powder ratio of 0.5 was packed in a split stainless mold and kept at room temperature for 24 hours to obtain set CaSO4·2H2O. The set CaSO4·2H2O was hydrothermally treated in the presence of disodium hydrogen phosphate (Na2HPO4) and sodium hydrogen carbonate (NaHCO3). The results of powder X-ray diffraction and Fourier transform infrared spectroscopy indicated that CO3Ap block could be fabricated from the set CaSO4·2H2O block by hydrothermal treatment with Na2HPO4 and NaHCO3. When the treatment temperature was increased, the conversion rate to CO3Ap increased. However, the carbonate content decreased with increasing treatment temperature.



Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin




S. Nomura et al., "Fabrication of Carbonate Apatite Block from Calcium Sulfate by Hydrothermal Treatment", Key Engineering Materials, Vols. 493-494, pp. 139-142, 2012

Online since:

October 2011




[1] K. Ishikawa, Bone Substitute Fabrication based on dissolution-precipitation reactions, Materials, 3 (2010) 1138-1155.

DOI: https://doi.org/10.3390/ma3021138

[2] X. Lin, S. Matsuya, A. Takeuchi, M. Nakagawa, Y. Terada, K. Ishikawa, Fabrication of carbonate apatite monolith by treatment of calcite in phosphate solutions, Arch. BioCeram. Res., 6 (2006) 37-39.

[3] Y. Suzuki, S. Matsuya, K. Udoh, M. Nakagawa, Y. Tsukiyama, K. Koyano, K. Ishikawa, Fabrication of hydroxyapatite block from gypsum block based on (NH4)2HPO4 treatment, Dent. Mater. J., 24 (2005) 515-521.

DOI: https://doi.org/10.4012/dmj.24.515

Fetching data from Crossref.
This may take some time to load.