Effect of Simulated Body Fluid on the Behaviour of Artificial Bone Composite Material Extended by Hydroxyapatite and Silicate Powders


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Bone matrix consists of organic and inorganic components. Organic phase mainly contributes to flexibility of bone while inorganic phase being responsible for the rigidity and hardness of the bone. Due to the biocompatibility of ceramics many forms of them have been used as the bone replacement and as the repair material. Hydroxyapatite which also exists in the natural structure of bone is one of those ceramics used as a component of bone cement. In order to modify the physical properties of prepared bone composite structures, some additives are included within the structure. In this study, a silicate material is included as an inorganic filler together with hydroxyapatite. Bis-GMA and HEMA were used as organic matrix. The prepared composites were than immersed in SBF and FTIR, SEM, hardness analyses were performed on the samples before and after the immersion. The results were reported in later part. It was observed that the precipitation of hydroxyapatite occurred after the immersion of samples in SBF and the hardness values were increased for each sample.



Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin




S. Yücel et al., "Effect of Simulated Body Fluid on the Behaviour of Artificial Bone Composite Material Extended by Hydroxyapatite and Silicate Powders", Key Engineering Materials, Vols. 493-494, pp. 159-165, 2012

Online since:

October 2011




[1] M. Saito, A. Maruoka, T. Mori, N. Sugano, K. Hino, Experimental studies on a new bioactive bone cement: hydroxyapatite composite resin. Biomaterials, 15 (1994) 156–60.

DOI: https://doi.org/10.1016/0142-9612(94)90266-6

[2] E.J. Harper, Bioactive bone cements. Proc. Inst. Mech. Eng. 212 (1998) 113–20.

[3] D. Ikeda, M. Saito, A. Murakami, T. Shibuya, K. Hino, T. Nakashima, Mechanical evaluation of a bio-active bone cement for total hip arthroplasty. Med Biol Eng Comput., 38 (2000) 401–5.

DOI: https://doi.org/10.1007/bf02345009

[4] V. Deram, C. Minichiello, R.N. Vannier, A. Le Maguer, L. Pawlowski, D. Murano, Microstructural characterizations of plasma sprayed hydroxyapatite coatings. Surface and Coatings Technology, 166 (2/3) (2003) 153−159.

DOI: https://doi.org/10.1016/s0257-8972(02)00855-1

[5] X. Wang, J. Wang, Y. Li, J. Feng, Y. Yan, M. Huang, A. Yang, Preparation of nanograde hydroxyapatite needle-like crystals under normal atmospheric pressure. High Technology Letters, 11 (2001) 92−94.

[6] J. Cizek, K.A. Khor, Z. Prochazka, Influence of spraying conditions on thermal and velocity properties of plasma sprayed hydroxyapatite. J. Mater. Sci. Eng. C., 27 (2) (2007) 340−344.

DOI: https://doi.org/10.1016/j.msec.2006.05.002

[7] L.L. Hench, Biomaterials: A forecast for the future. Biomaterials; 19 (1998) 1419–1423.

DOI: https://doi.org/10.1016/s0142-9612(98)00133-1

[8] L.L. Hench, R.J. Splinter, W.C. Allen, T.K. Greenlee, Bonding mechanisms at the interface of ceramic prosthetic materials. J. Biomed Mater Res Symp, 2 (1971) 117-41.

DOI: https://doi.org/10.1002/jbm.820050611

[9] T. Kokubo, Surface chemistry of bioactive glassceramics. J. Non-Cryst. Solids, 120 (1990a) 138-51.

[10] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Soultions able to reproduce in vivo surface-structure changes in bioactive glassceramic A-W. J. Biomed. Mater. Res., 24 (1990b) 721-34.

DOI: https://doi.org/10.1002/jbm.820240607

[11] T. Jaakkola, J. Rich, T. Tirri, T. Närhi, M. Jokinen, J. Seppälä, A. Yli-Urpo, In vitro Ca-P precipitation on biodegradable thermoplastic composite of poly(ε-caprolactone-co-DL-lactide) and bioactive glass (S53P4). Biomaterials, 25 (2004) 575-81.

DOI: https://doi.org/10.1016/s0142-9612(03)00558-1

[12] T. Niemelä, H. Niiranen, M. Kellomäki, P. Törmälä, Self-reinforced composites of bioabsorbable polymer and bioactive glass with different bioactive glass contents. Part I: Initial mechanical properties and bioactivity. Acta Biomaterialia 1, 1 (2005).

DOI: https://doi.org/10.1016/j.actbio.2004.11.002

[13] M. Brink, Bioactive glasses with a large working range. PhD Thesis, Abo Akademi University, Finland, (1997).

[14] T. Kokubo, H.M. Kim, F. Miyaji, H. Takadama, T. Miyazaki, Ceramic-metal and ceramic-polymer composites prepared by a biomimetic process. Composites Part A: Applied Science and Manufacturing, 30(4) (1999) 405−409.

DOI: https://doi.org/10.1016/s1359-835x(98)00127-4

[15] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Solution able to reproduce in vivo surfacestructure changes in bioactive glass-ceramic A-W. Journal of Biomedical Materials Research, , 24 (6) (1990) 721−734.

DOI: https://doi.org/10.1002/jbm.820240607

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