The Effect of Pore Forming Agent Particle Size on the Porosity, Microstructure and In Vitro Studies of Hydroxyapatite Ceramics
In situ viscous mass foaming with ammonium bicarbonate (NH4HCO3) as foaming agent was used for the preparation of porous hydroxyapatite ceramics. Three different particle fractions (100-300 μm, 300-500 μm, 500-1000 μm) of NH4HCO3 were used in order to evaluate the particle size effect on the ceramic microstructure. Foamed and dried green bodies were sintered at 1150°C. The porosity and microstructure of ceramics were determined with Archimedes method and scanning electron microscopy. As the NH4HCO3 particle fraction was decrease from 100-300 μm to 500-1000 μm, the open porosity increased from 42 to 54 %. In situ viscous mass foaming leads to the interconnected pore channels with wide pore size range (10-600 μm). In the present work cytotoxicity of obtained porous HA ceramics and fibroblast cell viability was investigated.
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
V. Zalite et al., "The Effect of Pore Forming Agent Particle Size on the Porosity, Microstructure and In Vitro Studies of Hydroxyapatite Ceramics", Key Engineering Materials, Vols. 493-494, pp. 277-280, 2012