The Impact of Stirring Rate on the Crystallinity and Bioactivity of 58S Bioactive Glass


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In most biphasic composite systems consisting of sol-gel derived bioactive glass and a second system that is usually used as a reinforcing agent, thorough stirring is necessary to prevent the precipitation of the grains of the second system. Consequently, the aim of this work is to investigate the impact of various stirring rates on the crystallinity and bioactivity of a bioactive glass in the system 58S. Sol-gel-derived bioactive glass (58S) was produced as described in literature. During the gelation, stirring rates of 0, 200, 400, 600 and 800 rpms were applied producing, respectively, the corresponding glass powders. The in vitro bioactivity of the powders was tested in Simulated Body Fluid (SBF) for various immersion times, while the solution was renewed after 6h, 24h and then every 2 days. Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and X-ray Diffractometry (XRD) were used to characterize all materials before and after immersion in SBF solution. FTIR and XRD measurements of all powders revealed mainly the formation of an amorphous glass, while the main crystalline phase was identified to be Ca2SiO4. After immersion in SBF solution for 12h, SEM microphotographs revealed apatite formation on the surface of all samples, while FTIR and XRD confirmed the aforementioned findings. Furthermore, since EDS analysis proved a mean molar Ca/P ratio of about1.7 after 6 days of immersion of all samples- besides those stirred at 400 and 600rpm- it can be assumed that a thick apatite layer was formed covering the whole surface.



Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin




O. M. Goudouri et al., "The Impact of Stirring Rate on the Crystallinity and Bioactivity of 58S Bioactive Glass", Key Engineering Materials, Vols. 493-494, pp. 43-48, 2012

Online since:

October 2011




[1] CJ Brinker, GW Scherer. The Physics and Chemistry of Sol–Gel Processing, New York: Academic Press; (1990).

[2] Y Tanaka, K Yamashita. Fabrication processes for bioceramics. In: Kokubo T, editor. Bioceramics and their clinical applications. Boca Raton, Boston, New York, Washington DC: CRC Press; (2008).

[3] P Saravanapavan, LL Hench, Mesoporous calcium silicate glasses. I. Synthesis, J Non-CrystSolids 318 (2003) 1–13.

[4] L Hench and J West, The Sol-Gel Process, Chem. Rev. 90 (1990) 33-72.

[5] O.M. Goudouri, E. Kontonasaki, A. Theocharidou, L. Papadopoulou, N. Kantiranis, X. Chatzistavrou, P. Koidis, K.M. Paraskevopoulos, Modifying a dental ceramic by bioactive glass via the sol–gel route: Characterization and bioactivity investigation, Materials Chemistry and Physics 125 (2011).

DOI: 10.1016/j.matchemphys.2010.09.054

[6] FW Yan, SF Zhang, CY Guo, XH Zhang, GC Chen, F Yan, GQ Yuan, Influence of stirring speed on the crystallization of calcium carbonate. Cryst Res Technol 44 (2009) 725 – 728.

DOI: 10.1002/crat.200900190

[7] MA Cheney, PK Bhowmik, S Moriuchi, M Villalobos, S Qian, SW Joo, The Effect of Stirring on the Morphology of Birnessite Nanoparticles, J Nanomater 2008 (2008): Article ID 168716.

DOI: 10.1155/2008/168716

[8] E Kondili, M Kontominas, M Kosmas, The effect of stirring on the diffusion of small molecules from a polymer matrix into a solution, Polymer 34 (1993) 2592-2596.

DOI: 10.1016/0032-3861(93)90594-z

[9] RC Reld, KR Sldman, AD Schwope, DE Till, Loss of Adjuvants from Polymer Films to Foods or Food Simulant. Effect of the External Phase, Ind. Eng. Chem. Prod. Res. Dev 19 (1980) 580-587.

DOI: 10.1021/i360076a019

[10] R Li, AE Clark, LL Hench, Effects of structure and surface area on bioactive powders by sol- gel process. In: Hench LL, West JK, editors. Chemical processing of advanced materials. New York: John Wiley & Sons, Inc.; (1992).

[11] J Zhong and DC Greenspan, Processing and Properties of Sol–Gel Bioactive Glasses, J. Biomed. Mater. Res. 53 (2000) 694-701.

DOI: 10.1002/1097-4636(2000)53:6<694::aid-jbm12>;2-6

[12] T Kokubo, H Kushitani, S Sakka, T Kitsugi, T Yamamuro, Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W3, J Biomed Mater Res 24, (1990) 721-34.

DOI: 10.1002/jbm.820240607

[13] Y Zhang, M Mizuno, M Yanagisawa, H Takadama, Bioactive behaviors of porous apatite- and wollastonite-containing glass-ceramic in two kinds of simulated body fluid, J Mater Res 18 (2003)433-441.

DOI: 10.1557/jmr.2003.0055

[14] Mullin J. Crystallization. Woburn: Butterwoth-Heinemann; (2001).

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