Nano Metallic-Oxides as Antimicrobials for Implant Coatings
The use of metallic nanoparticles in the field of orthopaedics as antimicrobial components of coatings is receiving particular attention. An innovative approach has been developed whereby various metal/metal oxide nanoparticles are used to prevent infection occurring on the surface of prostheses. In this study nano metallic oxides (zinc oxide - ZnO and tungsten oxide - WO3) were used. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of each nanoparticulate were determined against four species of bacteria (Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis and Pseudomonas aeruginosa). Subsequently the nanoparticles were prepared in a suspension of ethanol and sprayed onto the surface of glass using electrohydrodynamic deposition. Quantitative assessments as regards the antimicrobial properties of these coated samples were carried out. Comparisons of the antibacterial properties demonstrated that 2500 µg/ml or above of the oxides were required to kill the species of bacteria tested. WO3 was the most effective oxide tested in suspension using growth inhibition tests. However, coated samples demonstrated that ZnO was more bactericidal than WO3 under these conditions.
Eyup Sabri Kayali, Gultekin Goller and Ipek Akin
K. Memarzadeh et al., "Nano Metallic-Oxides as Antimicrobials for Implant Coatings", Key Engineering Materials, Vols. 493-494, pp. 489-494, 2012