Ion Release Behavior and Apatite-Forming Ability of Sol-Gel Derived 70S30C Bioactive Glass with Magnesium/Zinc Substitution


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Bioactive glasses not only can bond to hard tissues of the body, are also able to release ions that have stimulatory effects on cells and so are regarded as promising candidate materials for gene activating purposes in tissue engineering applications. In this research the effect of co-substitution of Magnesium and Zinc for Calcium on bioactivity of binary sol-gel derived glass 70S30C (70 mol. % SiO2, 30 mol. % CaO) was investigated. Calcium phosphates forming ability tests and investigation of glass degradation products in simulated body fluid (SBF) were performed as follows.After sol-gel synthesis of glass powders of comparable and under 38 μm particle size distributions, their state of being amorphous was investigated using X-ray diffraction. Then for in vitro investigation of bioactivity, ion release, pH change and Calcium phosphate formation during immersion of glass powders in SBF at 37 ͦ C up to 2 weeks were studied. Infrared spectroscopy was performed on the reacted glass powders.Results indicate that substitution of Zinc for Calcium suppresses crystalline apatite formation more effectively than substitution of Magnesium for Calcium and help us design modified compositions of magnesium and zinc containing bioactive glasses that can find applications in bone and also cartillage tissue engineering.



Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gültekin Göller and Ipek Akin




A.A. Hamedani et al., "Ion Release Behavior and Apatite-Forming Ability of Sol-Gel Derived 70S30C Bioactive Glass with Magnesium/Zinc Substitution", Key Engineering Materials, Vols. 493-494, pp. 55-60, 2012

Online since:

October 2011




[1] I.D. Xynos et. al., Ionic Products of Bioactive Glass Dissolution Increase Proliferation of Human Osteoblasts and Induce Insulin-like Growth Factor II mRNA Expression and Protein Synthesis, Biochem. Bioph. Res. Co., 276 (2000) 461-465.


[2] L.L. Hench, Genetic design of bioactive glass, J. Eur. Ceram. Soc., 29 (2009) 1257-1265.

[3] A. Hoppe, N.S. Guldal, A.R. Boccaccini, A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials, 32 (2011) 2757-2774.


[4] P. Saravanapavan, L.L. Hench, Mesoporous calcium silicate glasses. I. Synthesis, J. Non-cryst. Solids., 318 (2003) 1-13.


[5] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity? Biomaterials, 27 (2006) 2907-2915.


[6] D.S. Brauer et. al., Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid, Acta. Biomater., 6 (2010) 3275-3282.


[7] M. Bohner, J. Lemaitre, Can bioactivity be tested in vitro with SBF solution?, Biomaterials, 30 (2009) 2175-2179.


[8] M.M. Azevedo et. al., Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration, J. Mat. Chem., 20 (2010) 8854-8864.

[9] M. Erol, A. Ozyuguran, O. Celebican, Synthesis, Characterization, and In Vitro Bioactivity of Sol-Gel-Derived Zn, Mg, and Zn-Mg Co-Doped Bioactive Glasses, Chem. Eng. Technol., 33 (2010) 1066-1074.


[10] S.J. Watts et. al., Influence of magnesia on the structure and properties of bioactive glasses. J. Non-cryst. Solids., 356 (2010) 517-524.


[11] S. Lin et. al., Nanostructure evolution and calcium distribution in sol-gel derived bioactive glass. J. Mat. Chem., 19 (2009) 1276-1282.

[12] A. Balamurugan et. al., Development and in vitro characterization of sol-gel derived CaO-P2O5-SiO2-ZnO bioglass, Acta. Biomater., 3 (2007) 255-262.


[13] S. Haimi et. al., Characterization of zinc-releasing three-dimensional bioactive glass scaffolds and their effect on human adipose stem cell proliferation and osteogenic differentiation, Acta. Biomater., 5 (2009) 3122-3131.


[14] X. Lu, Y. Leng, Theoretical analysis of calcium phosphate precipitation in simulated body fluid, Biomaterials, 26 (2005)1097-1108.


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