Investigation of the Phase Separation Occurring during the Injection of β-Tricalcium Phosphate – Water – Glass Beads Pastes


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Tests were performed to assess the parameters influencing the injectability of cement pastes loaded with large particles, such as porogens or drug-delivery agents. The use of non-setting model pastes permitted to demonstrate that two phase separation mechanisms occurred simultaneously, i.e. the separation between liquid and powder, known as filter-pressing phenomenon, and the separation between larger and smaller particles.



Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin






S. Tadier et al., "Investigation of the Phase Separation Occurring during the Injection of β-Tricalcium Phosphate – Water – Glass Beads Pastes", Key Engineering Materials, Vols. 493-494, pp. 693-697, 2012

Online since:

October 2011




[1] M.P. Ginebra, M. Espanol, E.B. Montufar, R.A. Perez, G. Mestres, New processing approaches in calcium phosphate cements and their applications in regenerative medicine, Acta Biomaterialia 6 (8) (2010), 2863-2873.

DOI: 10.1016/j.actbio.2010.01.036

[2] M. Bohner, G. Baroud, Injectability of calcium phosphate pastes, Biomaterials 26 (13) (2005), 1553-1563.

DOI: 10.1016/j.biomaterials.2004.05.010

[3] M. Habib, G. Baroud, F. Gitzhofer, M. Bohner, Mechanisms underlying the limited injectability of hydraulic calcium phosphate paste, Acta Biomaterialia 4 (2008), 1465-1471.

DOI: 10.1016/j.actbio.2008.03.004

[4] L. Leroux, Z. Hatim, M. Freche, J.L. Lacout, Effects of various adjuvants (lactic acid, glycerol, and chitosan) on the injectability of a calcium phosphate cement, Bone 25(2) (1999), S31-S34.

DOI: 10.1016/s8756-3282(99)00130-1

[5] D. Apelt, F. Theiss, A.O. El-Warrak, K. Zlinszky, R. Bettschart-Wolfisberger, M. Bohner, S. Matter, J.A. Auer, B. von Rechenberg, In vivo behavior of three different injectable hydraulic calcium phosphate cements, Biomaterials 25 (2004).

DOI: 10.1016/j.biomaterials.2003.08.073

[6] S. Takagi, L.C. Chow, Formation of macropores in calcium phosphate cement implants, J. Mater. Sci.: Mater. Med. 12 (2001), 135-139.

[7] X. Qi, J. Ye, Y. Wang, Improved injectability and in vitro degradation of a calcium phosphate cement containing poly(lactide-co-glycolide) microspheres, Acta Biomaterialia 4 (2008), 1837-1845.

DOI: 10.1016/j.actbio.2008.05.009

[8] W.J.E.M. Habraken, J.G.C. Wolke, J.A. Jansen, Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering, Advanced Drug Delivery Reviews 59 (2007), 234-248.

DOI: 10.1016/j.addr.2007.03.011

[9] J. Schnieders, U. Gbureck, R. Thull, T, Kissel, Controlled release of gentamicin from calcium phosphate – poly(lactic acid-co-glycolic acid) composite bone cement, Biomaterials 27 (2006), 4239-4249.

DOI: 10.1016/j.biomaterials.2006.03.032

[10] L. Y. Sadler, K. G. Sim, Minimize solid-liquid mixture viscosity by optimizing particle size distribution, Chem. Eng. Progress 87 (3) (1991), 68-71.

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