Internal Diffusion of Biocompatible Polymer-Coated Inorganic Nanoparticles in Mice

Abstract:

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In this study, we succeeded in preparation and characterization of two types of biocompatible polymer-coated inorganic nanoparticles (cupper and silicone oxide). As a biocompatible polymer, gelatin and poly(lactic acid) were used. For determination of their biodistribution, the obtained particles were administered to mice through the tail vein. After administration, the particles in some organs were determined with energy-dispersed X-ray spectrometer. The cupper nanoparticles were observed in the lung and kidney, while the silica particles were in the lung, liver and spleen. The distribution behaviors were quite different from non-polymer coated nanoparticles

Info:

Periodical:

Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin

Pages:

752-756

DOI:

10.4028/www.scientific.net/KEM.493-494.752

Citation:

S. Abe et al., "Internal Diffusion of Biocompatible Polymer-Coated Inorganic Nanoparticles in Mice", Key Engineering Materials, Vols. 493-494, pp. 752-756, 2012

Online since:

October 2011

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Price:

$35.00

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