Fully-Interconnected Pore Forming Calcium Phosphate Cement


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Calcium phosphate cement that foams fully-interconnected porous structure along with its gradual replacement to bone may be ideal for bone defect reconstruction. In the present study, α-tricalcium phosphate (αTCP) microspheres were exposed to acidic calcium phosphate solution. It was found that the αTCP microspheres set in approximately 10 min to form fully-interconnected porous structure. The porosity was approximately 50% and the pore size was 300µm. The surface of the porous body was dicalcium phosphate dihydrate whereas the inside was αTCP.



Key Engineering Materials (Volumes 493-494)

Main Theme:

Edited by:

Eyup Sabri Kayali, Gultekin Goller and Ipek Akin




I. Kunio et al., "Fully-Interconnected Pore Forming Calcium Phosphate Cement", Key Engineering Materials, Vols. 493-494, pp. 832-835, 2012

Online since:

October 2011




[1] H. Monma, T. Kanazawa, The hydration of a-tricalcium phosphate, Yogyo-Kyokai-Shi, 84 (1976) 209-213.

[2] W.E. Brown, L.C. Chow, A new calcium phosphate, water-setting cement, in: P.W. Brown (Ed. ), Cement Research Progress, Westerville, USA, 1986, pp.351-379.

[3] J. Lemaitre, A. Mirtchi, A. Mortier, Calcium phosphate cements for medical uses: states of the art and perspectives of development. Sil Ind Ceram Sci Technol 52 (1987) 141-146.

[4] A.J. Ambard, L Mueninghoff, Calcium phosphate cement: Review of mechanical and biological properties. J Prosthodont 15 (2006) 321-328.

DOI: https://doi.org/10.1111/j.1532-849x.2006.00129.x

[5] H-H.K. Xu, S. Takagi, J-B. Quinn, L.C. Chow, Fast-setting calcium phosphate scaffolds with tailored macropore formation rates for bone regeneration, J. Biomed. Mater. Res., 68A (2004) 725–734.

DOI: https://doi.org/10.1002/jbm.a.20093

[6] A. Almirall, G. Larrecq, J.A. Delgado, S. Marta´nez, J.A. Planell, M.P. Ginebr, Fabrication of low temperature macroporous hydroxyapatite scaffolds by foaming and hydrolysis of an a-TCP paste. Biomaterials 25 (2004) 3671–80.

DOI: https://doi.org/10.1016/j.biomaterials.2003.10.066

[7] R. Shimogoryo, T. Eguro, E. Kimura, M. Maruta, S. Matsuya, K. Ishikawa, Effects of added mannitol on the setting reaction and mechanical strength of apatite cement. Dent Mater J, 28 (2009) 627-633.

DOI: https://doi.org/10.4012/dmj.28.627

[8] S. Karashima, A. Takeuchi, S. Matsuya, K. Udoh, K. Koyano, K. Ishikawa, Fabrication of low-crystallinity hydroxyapatite foam based on the setting reaction of alpha-tricalcium phosphate foam. J Biomed Mater Res A. 88 (2009) 628-633.

DOI: https://doi.org/10.1002/jbm.a.31904

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