Synthesis and Characterization of Cx-Siy-HA for Bone Tissue Engineering Application

Abstract:

Article Preview

The main goal of this work is to prepare carbon and silicon co-substituted calcium hydroxyapatite (Cx-Siy-HA) for bone tissue engineering application. This study includes the synthesis of pure powders with a controlled amount of carbonate (x) and silicate (y) ions within the apatite structure, their characterization with the establishment of database for different compositions, and the manufacture of dense bioceramics. Carbon-silicon co-substituted hydroxyapatite (C0.5-Si0.5-HA) powders are synthesized by aqueous precipitation. According to structural, spectroscopic and elemental characterizations, silicate and carbonate are included in the apatite lattice and their stoichiometries are controlled. The heat treatments under CO2 atmosphere allow the sintering of pellets without decomposition of the apatite structure.

Info:

Periodical:

Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

100-104

Citation:

A. Boyer et al., "Synthesis and Characterization of Cx-Siy-HA for Bone Tissue Engineering Application", Key Engineering Materials, Vols. 529-530, pp. 100-104, 2013

Online since:

November 2012

Export:

Price:

$38.00

[1] J.C. Elliott, Structure and chemistry of the apatites and other calcium orthophosphates, Studies in Organic Chemistry, (1994).

[2] F. Driessens, H. Schaeken, R. Verbeeck, On the mechanism of subsitution in carbonated apatites, Journal of Dental Research, 62 (1983) 455.

[3] G. Montel, G. Bonel, J.C. Heughebaert, J.C. Trombe, C. Rey, New concepts in the composition, crystallization and growth of the mineral component of calcified tissues, Journal of Crystal Growth, 53 (1981) 74–99.

DOI: https://doi.org/10.1016/0022-0248(81)90057-9

[4] C. Rey, B. Collins, T. Goehl, I.R. Dickson, M.J. Glimcher, The carbonate environment in bone mineral: A resolution-enhanced fourier transform infrared spectroscopy study, Calcified Tissue International, 45 (1989) 157–164.

DOI: https://doi.org/10.1007/bf02556059

[5] J. Barralet, S. Best, W. Bonfield, Effect of sintering parameters on the density and microstructure of carbonate hydroxyapatite, J. Mater. Sci. -Mater. Med., 11 (2000) 719–724.

[6] Z. Zyman, M. Tkachenko, CO2 gas-activated sintering of carbonated hydroxyapatites, Journal of the European Ceramic Society, 31 (2011) 241–248.

DOI: https://doi.org/10.1016/j.jeurceramsoc.2010.09.005

[7] E.M. Carlisle, Silicon: A Possible Factor in Bone Calcification, Science, 167 (1970) 279–280.

[8] D. Marchat, M. Zymelka, L. Gremillard, C. Coelho, L. Joly-Pottuz, F. Babonneau, C. Esnouf, J. Chevalier, D. Bernache-Assollant, Accurate characterization of silicon-substituted hydroxyapatites powders synthesized by a new precipitation route, Acta Biomaterialia, 2012, Submitted.

DOI: https://doi.org/10.1016/j.actbio.2013.03.011

[9] E. Landi, J. Uggeri, S. Sprio, A. Tampieri, S. Guizzardi, Human osteoblast behavior on as-synthesized SiO4 and B-CO3 co-substituted apatite, Journal of Biomedical Materials Research Part A, 94A (2010) 59–70.

DOI: https://doi.org/10.1002/jbm.a.32671

[10] T. Huang, Y. Xiao, S. Wang, Y. Huang, X. Liu, F. Wu, Z. Gu, Nanostructured Si, Mg, CO32- Substituted Hydroxyapatite Coatings Deposited by Liquid Precursor Plasma Spraying: Synthesis and Characterization, Journal of Thermal Spray Technology, 20 (2011).

DOI: https://doi.org/10.1007/s11666-011-9628-y

[11] D.M. Ibrahim, A.A. Mostafa, S.I. Korowash, Chemical characterization of some substituted hydroxyapatites, Chem Cent J, 5 (2011) 74.

[12] N.Y. Mostafa, H.M. Hassan, O.H. Abd Elkader, Preparation and Characterization of Na+, SiO44-, and CO32- Co-Substituted Hydroxyapatite, Journal of the American Ceramic Society, 94 (2011) 1584–1590.

DOI: https://doi.org/10.1111/j.1551-2916.2010.04282.x

[13] N.Y. Mostafa, H.M. Hassan, F.H. Mohamed, Sintering behavior and thermal stability of Na+, SiO44- and CO32- co-substituted hydroxyapatites, Journal of Alloys and Compounds, 479 (2009) 692–698.

DOI: https://doi.org/10.1016/j.jallcom.2009.01.037

[14] J. Lafon, E. Champion, D. Bernache-Assollant, R. Gibert, A. Danna, Thermal decomposition of carbonated calcium phosphate apatites, Journal of Thermal Analysis and Calorimetry, 72 (2003) 1127–1134.

DOI: https://doi.org/10.1023/a:1025036214044

[15] J.P. Lafon, E. Champion, D. Bernache-Assollant, Processing of AB-type carbonated hydroxyapatite Ca10-x(PO4)6-x(CO3)x(OH)2-x-2y(CO3)y ceramics with controlled composition, Journal of the European Ceramic Society, 28 (2008) 139–147.

DOI: https://doi.org/10.1016/j.jeurceramsoc.2007.06.009

[16] J. Barralet, J. Knowles, S. Best, W. Bonfield, Thermal decomposition of synthesised carbonate hydroxyapatite, J. Mater. Sci. -Mater. Med., 13 (2002) 529–533.