Synthesis and Characterization of Cx-Siy-HA for Bone Tissue Engineering Application
The main goal of this work is to prepare carbon and silicon co-substituted calcium hydroxyapatite (Cx-Siy-HA) for bone tissue engineering application. This study includes the synthesis of pure powders with a controlled amount of carbonate (x) and silicate (y) ions within the apatite structure, their characterization with the establishment of database for different compositions, and the manufacture of dense bioceramics. Carbon-silicon co-substituted hydroxyapatite (C0.5-Si0.5-HA) powders are synthesized by aqueous precipitation. According to structural, spectroscopic and elemental characterizations, silicate and carbonate are included in the apatite lattice and their stoichiometries are controlled. The heat treatments under CO2 atmosphere allow the sintering of pellets without decomposition of the apatite structure.
Kunio Ishikawa and Yukihide Iwamoto
A. Boyer et al., "Synthesis and Characterization of Cx-Siy-HA for Bone Tissue Engineering Application", Key Engineering Materials, Vols. 529-530, pp. 100-104, 2013