Characterization and In Vitro Evaluation of Silicate-Containing Tricalcium Phosphate Prepared through Wet Chemical Process

Abstract:

Article Preview

Tricalcium phosphate (TCP) ceramics are useful biodegradable bone-repairing materials. Silicate-containing TCP ceramics are expected to be useful as biodegradable bone-repairing materials which promote the bone regeneration because it has been reported that the silicate promotes bone formation. In the present study, silicate-containing TCP ceramics were prepared through a wet chemical process at the starting compositions from 0 to 0.05 in the Si/(P+Si) molar ratio. The prepared silicate-containing TCP ceramics were characterized and evaluated in vitro. The crystal phase of the products was α-TCP, and the tendency that the lattice constants linearly shifted from 0 to 0.05 in the starting Si/(P+Si) molar ratio was observed. It is speculated that the added silicate was incorporated in the crystal structure of TCP. The pellets were prepared by a sintering process, and soaked in a simulated body fluid (SBF) to estimate their bone-bonding ability. The addition of silicate to TCP promoted to hydroxyapatite formation on the TCP ceramics in SBF. This result implies the high possibility that the silicate addition would promote the bone-bonding ability of the TCP ceramics.

Info:

Periodical:

Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

105-108

Citation:

M. Kamitakahara et al., "Characterization and In Vitro Evaluation of Silicate-Containing Tricalcium Phosphate Prepared through Wet Chemical Process", Key Engineering Materials, Vols. 529-530, pp. 105-108, 2013

Online since:

November 2012

Export:

Price:

$38.00

[1] L.L. Hench, Bioceramics: from concept to clinic, J. Am. Ceram. Soc. 74 (1991) 1487-1510.

[2] R.W. LeGeros, Properties of osteoconductive biomaterials: calcium phosphates, Clin. Orthop. Relat. Res. 395 (2002) 81-98.

[3] B.V. Rejda, J.G.J. Peelen, K.D. de Groot, Tricalcium phosphate as a bone substitute, J. Bioeng. 1 (1977) 93-97.

[4] E.M. Carlisle, Silicon: a possible factor in bone calcification, Science 167 (1970) 279-280.

[5] I.R. Gibson, S.M. Best, W. Bonfield, Chemical characterization of silicon-substituted hydroxyapatite, J. Biomed. Mater. Res. 44 (1999) 422-428.

DOI: https://doi.org/10.1002/(sici)1097-4636(19990315)44:4<422::aid-jbm8>3.0.co;2-#

[6] J.W. Reid, A. Pietak, M. Sayer, D. Dunfield, T.J.N. Smith, Phase formation and evolution in the silicon substituted tricalcium phosphate/apatite system, Biomaterials 26 (2005) 2887-2897.

DOI: https://doi.org/10.1016/j.biomaterials.2004.09.005

[7] J.W. Reid, L. Tuck, M. Sayer, K. Fargo, J.A. Hendry, Synthesis and characterization of single-phase silicon-substituted a-tricalcium phosphate, Biomaterials 27 (2006) 2916-2925.

DOI: https://doi.org/10.1016/j.biomaterials.2006.01.007

[8] M. Kamitakahara, T. Kurauchi, M. Tanihara, K. Ioku, C. Ohtsuki, Synthesis of Si-containing tricalcium phosphate and its sintering behavior, Key. Eng. Mater. 361-363 (2008) 59-62.

DOI: https://doi.org/10.4028/www.scientific.net/kem.361-363.59

[9] M. Kamitakahara, H. Kamura, N. Watanabe, K. Ioku, C. Ohtsuki, Synthesis of Silicon-doped tricalcium phosphate through wet chemical process, Proceedings of 22nd International Symposium on Ceramics in Medicine (2009) 31-34.

[10] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W, J. Biomed. Mater. Res. 24 (1990) 721-734.

DOI: https://doi.org/10.1002/jbm.820240607

[11] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity?, Biomaterials 27 (2006) 2907-2915.

DOI: https://doi.org/10.1016/j.biomaterials.2006.01.017

[12] P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura, T. Yamamuro, Apatite formation induced by silica gel in a simulated body fluid, J. Am. Ceram. Soc. 75 (1992) 2094-(2097).

DOI: https://doi.org/10.1111/j.1151-2916.1992.tb04470.x

[13] H. Takadama, H. -M. Kim, F. Miyaji, T. Kokubo, T. Nakamura, Mechanism of apatite formation induced by silanol groups - TEM observation, J. Ceram. Soc. Jpn. 108 (2000) 118-121.

DOI: https://doi.org/10.2109/jcersj.108.1254_118