Characteristics and Bioactivity of CaP Porous Coating with Bio-Inspired Dopamine


Article Preview

mplants made of titanium and its alloys are widely used in dental and orthopedic fields due to their excellent chemical stability and mechanical properties. However, due to the bio-inert properties of titanium and its alloys, it is difficult to achieve a chemical bond with bone tissue and to form a new bond on the surface. To improve biocompatibility, surface treatments are often used to modify the chemical and morphological properties. Besides, the mussel-inspired molecule of 3,4-dihydroxy-L-phenylalanine (dopamine) shows excellent biological responses. The aim of this study is to investigate the physicochemical and biomedical properties of CaP porous coating with dopamine. The CaP porous coating was prepared on titanium by micro-arc oxidation, and then bio-inspired molecular of dopamine modified surface to improve the cell behavior. Characteristics of the morphology, chemical composition, and interfacial properties of dopamine-functionalized CaP porous architecture was performed by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The osteoblastic cell behaviour, such as differentiation and morphology is evaluated. The nitrogen signal in XPS spectrum was indicated that the dopamine existed in the porous coating. The anatase and rutile phases of porous coating with dopamine were identified. Morphologies of porous coating with dopamine showed the uniform and three-dimensional structure. Cell culture experiments demonstrate that the porous coating with dopamine would improve cell behavior. All findings in this study indicated that CaP porous coating with dopamine have good bioactivity for clinical applications.



Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto




Y. T. Liu et al., "Characteristics and Bioactivity of CaP Porous Coating with Bio-Inspired Dopamine", Key Engineering Materials, Vols. 529-530, pp. 233-236, 2013

Online since:

November 2012




[1] L.H. Li, Y.M. Kong, H.W. Kim, Y.W. Kim, H.E. Kim, S.J. Heo, J.Y. Koak, Improved biological performance of Ti implants due to surface modification by micro-arc oxidation, Biomaterials, 25 (2004) 2867-75.


[2] Y.T. Sul, The significance of the surface properties of oxidized titanium to the bone response: special emphasis on potential biochemical bonding of oxidized titanium implant, Biomaterials, 24 (2003) 3893-3907.


[3] K.C. Kung, T.M. Lee, J.L. Chen, T.S. Lui, Characteristics and biological responses of novel coatings containing strontium by micro-arc oxidation, Surf. Coat. Technol., 205 (2010) 1714-1722.


[4] H. Lee, N.F. Scherer, P.B. Messersmith, Single-molecule mechanics of mussel adhesion. P. Natl. Acad. Sci. USA, 103 (2006) 12999-123003.

[5] H. Lee, S.M. Dellatore, W.M. Miller, P.B. Messersmith, Mussel-inspired surface chemistry for multifunctional coatings, Science, 318 (2007) 426-430.