Bone Grafting Putty – Animal Experiments and Clinical Applications


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The aim of the described study was to generate and evaluate a putty-like bone graft substitute ready to use for dental and orthopedic surgery. According to the asking of clinicians the new material should avoid the necessity of mixing blood and bone graft during the surgical process. Therefor the granulous material NanoBone® has been combined with a hydrogel based on Polyvinylpyrrolidone (PVP) and tested in standardized rat tibia defect over a period of 12 weeks and evaluated histologically. The results showed no limitations of the granulate characteristics in matrix change and hence a high level of vascularization and bone formation. An example for dental application shows the outcome in the case of socket preservation.



Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto




T. Gerber et al., "Bone Grafting Putty – Animal Experiments and Clinical Applications", Key Engineering Materials, Vols. 529-530, pp. 285-290, 2013

Online since:

November 2012




[1] Ganz C, Xu W, Holzhüter G, Götz W, Vollmar B, Gerber T. Comparison of bone substitutes in a tibia defect model in Wistar-rats. Key Engineering Materials Vols. 493-494 2012; pp.732-738.


[2] Vignoletti F, Matesanz P, Rodrigo D, Figuero E, Martin C, Sanz M. (2012) Surgical protocols for ridge preservation after tooth extraction. A systematic review. Clin Oral Implants Res. Suppl 5: 22-38.