In Vivo Comparative Study of Two Injectable/Moldable Calcium Phosphate Bioceramics


Article Preview

Calcium phosphate bioceramic granules associated with hydrosoluble polymers formed putties currently more used in clinical applications as they are easy to handle (injectability, moldability). In this study, 2 kinds of materials were tested in rabbit bone defects. The first one is InOss (Biomatlante), a microporous biphasic CaP granules (BCP, HA/TCP mixture) with polysaccharidic hydrogel; and the second one is Actifuse ABX (Baxter/Apatech), pure hydroxyapatite granules containing silicate (HA-Si) with blocks copolymer hydrogel (poloxamer), . The aim of this study was to compare osteogenic properties of two kinds of CaP putties containing HA-Si versus BCP and the kinetic of resorption of their hydrogel. Data have demonstrated that both hydrogels increase the handling properties. Bone regeneration was observed in the two types of sample, however at 3 weeks, Actifuse ABX hydrogel was not totally absorbed, while InOss hydrogel was no longer observed. The second difference observed was osteoconduction. Newly formed bone over the time period studied was moreover in close contact with BCP granules than with HA-Si granules. Larger granules resorption on time was observed for BCP compared to HA-Si. Resorption of Actifuse ABX remains limited and explains the faster kinetic of absorption for InOss. This study demonstrates biocompatibility, absorbability and bone ingrowth at the expense of the two types of putty injectable/moldable bioceramic used for bone regeneration.



Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto




T. Miramond et al., "In Vivo Comparative Study of Two Injectable/Moldable Calcium Phosphate Bioceramics", Key Engineering Materials, Vols. 529-530, pp. 291-295, 2013

Online since:

November 2012


[1] C.J. Stankewich, M.F. Swionthowski, A.F. Tencer, J. Ortho Res 4 (1996) 786-793.

[2] K. Ishikawa, In Bioceramics and their clinical applications, ed Kokubo T., Woodhead publishing in materials, Boca Raton USA, 2008, pp.438-463.

[3] G. Daculsi et al., Bone 25 (1999) 59-61.

[4] CNRS patent, WO 95/21634 GR3034590 (T3)", 2001-01-31.

[5] K. Hing et al., Biomaterials; 27 (2006) 5014-5026.

[6] G. Daculsi et al.,. J Mater Sci Mater Med 21(3) (2010) 855-861.

[7] S. Dorozhkin, J. Funct. Biomater. 1 (2010) 22-107.

[8] S. Samizadeh et al., 9th world Biomaterials Congress, proceeding, Chengdu China, (2012).

[9] M. Bohner, Biomaterials 30 (2009) 6403-6406.

[10] R. Legeros et al., Bioactive Bioceramics, Orthopaedic Biology and Medicine: Musculoskeletal Regeneration, Biological materials and methods. Ed W.S. Pietrazak Humana press, Totowa NJ USA, 2009, pp.153-181.

[11] G. Daculsi, R. LeGeros, Bioceramics and theirs clinical applications, T. Kokubo editor, Woodhead publishing, 2008, pp.395-424.

[12] D. Le Nihouannen et al., Bone 36(6) (2005) 1086-1093.

[13] O. Gauthier et al., J Mater Sci: Mat in Med 10 (1999) 199-204.

[14] O. Gauthier et al., J Biomed Mater Res, 47(1) (1999) 28-35.

[15] L. Le Guehennec et al., Eur Cell Mater. 13; 8 (2004) 1-11.

Fetching data from Crossref.
This may take some time to load.