Preclinical and Clinical Cases of New Absorbable Composite Interference Screws in Osteoarticular Surgery


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The objective of this study deals with preclinical and clinical cases of absorbable composite interference screws of next generation in osteoarticular surgery. These implants are made of resorbable polymers PLA either amorphous or semi-cristalline, associated with granules of microporous biphasic calcium phosphate ceramic. A preclinical study was performed on goats in femoral and tibial epiphysis during 4 and 6 months. Histological and histomorphometric results were obtained by micro CT, light and scanning electron microscopy. The comparative statistical in vivo study of the kinetics of resorption and bone regeneration have shown the superiority of the composite compared to control (polymer alone). Thus the presence of Biphasic Calcium Phosphate granules in the composite has a major role for bone regeneration at the expense of the implant (buffering effect and properties of osteoconduction). An observational and functional study involving 10 patients, with a follow-up from 17 to 33 months (mean 25.7), was performed. Data were analyzed according to Good Clinical Practice and International Conference on Harmonisation. Clinical observations have revealed no complications and no serious event was reported; quantitative functional indices confirm the good observational results. The clinical study supports the functionality and performance of this new composite with properties of osteoconduction related to the osteogenicity of microporous biphasic calcium phosphate granules in the field of knee ligament fixation.



Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto




A. P. Uzel et al., "Preclinical and Clinical Cases of New Absorbable Composite Interference Screws in Osteoarticular Surgery", Key Engineering Materials, Vols. 529-530, pp. 325-330, 2013

Online since:

November 2012




[1] R. LeGeros, J. LeGeros, Hydroxyapatite, In: T. Kokubo editors, Bioceramics and their clinical applications. New York: CRC Press; 2008. pp.367-394.

DOI: 10.1533/9781845694227.2.367

[2] G. Daculsi, R. LeGeros, In: T. Kokubo editors, Bioceramics and theirs clinical applications. New York: CRC Press; 2008. pp.395-423.

[3] JB. Park, RS. Lakes, Biomaterials: An Introduction, Second Edition, New York: Plenum Publishing; 1992. p.394.

[4] SW. Shalaby, editors. Biomedical Polymers Munich: Hanser Publishers, 1994, p.263.

[5] JC. Middleton, AJ. Tipton, Biomaterials 21 (2000) 2335-2346.

[6] D. Garlotta, J Polym Envir 19 (2001) 63-84.

[7] PA. Gnattillake, R. Adhikari, Europ. Cells and Mat. 5 (2003) 1-16.

[8] M. Vert, S. Li, H. Garreau, J. Control. Rel. 16 (1991) 15-26.

[9] S. Li, J. Biomed. Mater. Res. Appl. Biomater. 48 (1999) 342-353.

[10] AM. Rotunda, RS. Narins, Dermatol. Ther. 19 (2006) 151-58.

[11] O.M. Bostman J. Bone Joint Surg. Br. 80 (1998) 333-338.

[12] O.M. Bostman, H.K. Pihlajamaki, J. Bone Joint Surg. Br.; 80 (1998) 1791-1794.

[13] J.E. Bergsma, W.C. de Bruijn, F.R. Rosema, R.R. Bos, G. Boering, Biomaterials 16 (1995) 25-31.

[14] N. Magarelli et al. Int. J. Immunopathol. Pharmacol. 20 (2007) 207-211.

[15] F.A. Barber, M.H. Boothby, Arthroscopy 23 (2007) 476-481.

[16] H. Roberta et al., Orthopaedics & Traumatology: Surgery & Research 95 (2009) 171-176.

[17] G. Lajtai et al., Arthroscopy 17 (2001) 597-602.

[18] A.M. Rotunda, R.S. Narins, Dermatol Ther. 19(3) (2006) 151-158.

[19] M. Johnston et al., Arthroscopy 27(12) (2011) 1671-1678.

[20] FA. Barber, WD. Dockery, Arthroscopy 24 (2008) 441-447.

[21] WH. Warden et al., Arthroscopy 24 (2008) 370-373.

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