Osteoinductive Coating on PEEK Surfaces by Using Nanocrystalline Biomaterial and In Vivo Test


Article Preview

A surface coating on the polymer polyetheretherketone (PEEK) was developed to improve the osteointegration of an implantation model for cages (implant for spinal fusion). In a process of induction heating the polymer surface was coated with a synthetic biomaterial. The polymer surface melts during the coating process and crawls into the nanoporous structure of the biomaterial. After heat dissipation, a strong connection is reached between polymer and biomaterial. Finally, the model was implanted into New Zealand rabbit femur as control and coated group for 2, 4 and 6 weeks. The evaluation offers a ca. 10% higher bone-to-implant-contact value for the coated group.



Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto




H. Keuer et al., "Osteoinductive Coating on PEEK Surfaces by Using Nanocrystalline Biomaterial and In Vivo Test", Key Engineering Materials, Vols. 529-530, pp. 345-349, 2013

Online since:

November 2012




[1] S. M. Kurtz and J. N. Devine, PEEK Biomaterials in Trauma, Orthopedic, and Spinal Implants, Biomaterials 28 (2007) 4845-4869.

DOI: https://doi.org/10.1016/j.biomaterials.2007.07.013

[2] H. B. Skinner, Composite Technology for Total Hip Arthroplasty, Clinical Orthopaedics and Related Research 235 (1988) 224-236.

DOI: https://doi.org/10.1097/00003086-198810000-00022

[3] M. S. A. Bakar et al, Tensile properties, tension–tension fatigue and biological response of polyetheretherketone–hydroxyapatite composites for load-bearing orthopedic implants, Biomaterials 24 (2003) 2245-2250.

DOI: https://doi.org/10.1016/s0142-9612(03)00028-0

[4] C. -M. Han, The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties, Biomaterials 31 (2010) 3465-3470.

DOI: https://doi.org/10.1016/j.biomaterials.2009.12.030

[5] W. Götz et al, Immunohistochemical characterization of nanocrystalline hydroxyapatite silica gel (NanoBone®) osteogenesis: a study on biopsies from human jaws, Clinical Oral Implants Research 19 (2008) 1016-1026.

DOI: https://doi.org/10.1111/j.1600-0501.2008.01569.x

[6] W. Xu et al, Early matrix change of a nanostructured bone grafting substitute in the rat, Journal of Biomedical Materials Research Part B: Applied Biomaterials 91B (2009) 692-699.

DOI: https://doi.org/10.1002/jbm.b.31445