Nerve Regeneration by Using of Chitosan-Silicate Hybrid Porous Membranes

Abstract:

Article Preview

The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.

Info:

Periodical:

Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

361-364

Citation:

Y. Shirosaki et al., "Nerve Regeneration by Using of Chitosan-Silicate Hybrid Porous Membranes", Key Engineering Materials, Vols. 529-530, pp. 361-364, 2013

Online since:

November 2012

Export:

Price:

$38.00

[1] B. Schlosshauer, L. Dreesmann, H.E. Schaller, N. Sinis, Neurosurgery 59 (2006) 740-747.

[2] T. Chandy, C.P. Sharma, Artif. Cells Artif. Organs 18, (1990) 1-24.

[3] Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M.A. Lopes, J.D. Santos, M.H. Fernandes, Biomaterials 26, (2005) 485-493.

DOI: https://doi.org/10.1016/j.biomaterials.2004.02.056

[4] Y. Shirosaki, Y. Okayama, K. Tsuru, S. Hayakawa, A. Osaka, Chem. Eng. J. 137, (2008) 122-128.

[5] Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M.A. Lopes, J.D. Santos, M.A. Costa, M.H. Fernandes, Acta Biomaterialia 5, (2009) 346-355.

[6] D. Masters, C. Berde, D. Futta, C. Griggs, D. Hu, W. Kupsky, Anesthesiology 79, (1993) 340-346.