Processing and Characterization of a Composite of Hyaluronic Acid (HA) and Microspheres Biphasic Calcium Phosphate (BCP) for Dermal Repair

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Dermal fillers are injectable implants made of biological materials (collagen, autologous fat and hyaluronic acid animal) or synthetic (PMMA microparticles of hydroxyapatite and non-animal hyaluronic acid), biodegradable or not, that include features such as ideal biocompatibility, durability, non-profile migration and ability to promote a smooth, natural-looking correction. Its main indication is intended to treat contour defects caused by aging, photo damage, disease, trauma or scarification. The fact of biodegradable fillers are absorbed within a year after application resulted in the emergence of products permanent and semi-permanent to offer patients long-lasting effects. Currently, one of the most effective strategies has been the development of scaffolds formed by combining two or more biomaterials seeking the restoration of tissue function. The bioceramic associated with water-soluble polymers have been developed as substitutes for the repair of soft tissues with optimal biological response. The objective of this study was to process and characterize a composite hydrogel in the form of hyaluronic acid (HA) microspheres and biphasic calcium phosphate (BCP) in order injectable applications for repair of soft tissue. The powders of HA and BCP were characterized by Infrared Spectroscopy Fourier Transform (FTIR) and X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The characterization of the hydrogel injectability pure and the composite with different ratios of HA and BCP was performed. The components were characterized compatible for use as dermal fillers. The composite of hyaluronic acid (HA) and biphasic calcium phosphate (BCP) had adequate characterization and injetabilidade proving to be a potential candidate for restoration of soft tissue.

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Periodical:

Key Engineering Materials (Volumes 529-530)

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Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

421-425

Citation:

E. S. Silva et al., "Processing and Characterization of a Composite of Hyaluronic Acid (HA) and Microspheres Biphasic Calcium Phosphate (BCP) for Dermal Repair", Key Engineering Materials, Vols. 529-530, pp. 421-425, 2013

Online since:

November 2012

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$38.00

[1] JACOVELLA, P. F. Use of calcium hydroxylapatite (Radiesse®). Clinical Interventions in Aging, Argentina, v. 3, p.161–174, (2008).

DOI: https://doi.org/10.2147/cia.s2065

[2] CARPINTERO, I. S.; CANDELAS, D.; RODRIGUEZ, R. R. Materiales derelleno: tipos, indicaciones y complicaciones. Actas Dermosifiliogr, Madrid, v. 101, n. 5, pp.381-393, (2010).

DOI: https://doi.org/10.1016/j.ad.2010.01.004

[3] FREDRICKON, G. H.; TEZEL, A. The science of hyaluronic acid dermal fillers. Journal of Cosmetic and Laser Therapy, v. 10, pp.35-42. (2008).

DOI: https://doi.org/10.1080/14764170701774901

[4] JONES, D. Preenchedores dérmicos. In: GOLDBERG, D. J. Rejuvenescimento Facial. [S. l. ]: Ganabara Koogan, 2008. Cap. 5, p.228.

[5] REDBORD, K. P.; BUSSO, M.; HANKE, C. W. Soft-tissue augmentation with hyaluronic acid and calcium hydroxyl apatite fillers. Dermatologic Therapy, v. 24, pp.71-81, (2011).

DOI: https://doi.org/10.1111/j.1529-8019.2010.01380.x

[6] ALVES, H. L. R.; SANTOS, L. A.; BERGMANN, C. P. Injectability evaluation of tricalcium phosphate bone cement. J. Mater. Sci.: Mater. Med., n. 19, pp.241-246, (2008).

[7] SUNDARAM, H.; VOIGTS, B.; BEER, K. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg , v. 36, p.1859–1865, (2010).

DOI: https://doi.org/10.1111/j.1524-4725.2010.01743.x