Paper Title:
The Controlled Release of Simvastatin from Biomimetic Macrospheres
  Abstract

Simvastatin has been shown to succesfully stimulate bone regeneration and attention has being focussed on developing appropriate delivery carriers for its release. The challenge of deliverying therapeutic concentration of pharmaceutical compunds has being the centre of focus in drug delivery developments. This study examines the in-vivo effects of simvastatin released from β-TCP macrospheres derived from coral exoxskeletons. The results indicates that the controlled release of simvastatin can promote bone formation comparable with direct injection. Furthermore the results showed that the release of simvastatin delivery rates can be controlled by additional coating of an apatite coating. Analysis by CT scans, SEM, amount of new bone formed and mechanical strength tests, showed that by controlling the release of simvastatin bone formation can be stimulated to a therapeutic level.

  Info
Periodical
Key Engineering Materials (Volumes 529-530)
Main Theme
Chapter
VIII. Drag Delivery Carriers
Edited by
Kunio Ishikawa and Yukihide Iwamoto
Pages
461-464
DOI
10.4028/www.scientific.net/KEM.529-530.461
Citation
J. Chou, T. Ito, M. Otsuka, B. Ben-Nissan, B. Milthorpe, "The Controlled Release of Simvastatin from Biomimetic Macrospheres", Key Engineering Materials, Vols. 529-530, pp. 461-464, 2013
Online since
November 2012
Export
Price
$35.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: You Rong Duan, Cheng Yong Wang, Ji Yong Chen, Xing Dong Zhang
351
Authors: Hai Long Yang, Shouichi Somegawa, Ying Jie Yang, Zhi Chen Luo
617
Authors: Racquel Z. LeGeros, John P. LeGeros
Abstract:Plasma-sprayed ‘HA’ coatings on commercial orthopedic and dental implants were developed to combine the strength of the metal (Ti or Ti...
203
Authors: Li Ping Wang, Bang Cheng Yang, Ji Yong Chen, Xing Dong Zhang
Abstract:The bioactivities of titanium oxide film on titanium surface received from different chemical treatment methods were studied in SBF in vitro...
545
Authors: Christophe Drouet, Ronan Barré, Gérard Brunel, Gérard Dechambre, Edmond Benqué, Christèle Combes, Christian Rey
Abstract:Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in...
1237