The Controlled Release of Simvastatin from Biomimetic Macrospheres

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Simvastatin has been shown to succesfully stimulate bone regeneration and attention has being focussed on developing appropriate delivery carriers for its release. The challenge of deliverying therapeutic concentration of pharmaceutical compunds has being the centre of focus in drug delivery developments. This study examines the in-vivo effects of simvastatin released from β-TCP macrospheres derived from coral exoxskeletons. The results indicates that the controlled release of simvastatin can promote bone formation comparable with direct injection. Furthermore the results showed that the release of simvastatin delivery rates can be controlled by additional coating of an apatite coating. Analysis by CT scans, SEM, amount of new bone formed and mechanical strength tests, showed that by controlling the release of simvastatin bone formation can be stimulated to a therapeutic level.

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Periodical:

Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

461-464

Citation:

J. Chou et al., "The Controlled Release of Simvastatin from Biomimetic Macrospheres", Key Engineering Materials, Vols. 529-530, pp. 461-464, 2013

Online since:

November 2012

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$38.00

[1] Ayukawa Y, Okamura A, Koyano K. (2004). Simvastatin promotes osteogenesis around titanium implants. Clin Oral Implants Res. 15: 346-350.

DOI: https://doi.org/10.1046/j.1600-0501.2003.01015.x

[2] Chou J, Ben-Nissan B, Green DW, Valenzuela SM, Kohan L. Targeting and Dissolution Characteristics of Bone Forming and Antibacterial Drugs by Harnessing the Structure of Microspherical Shells from Coral Beach Sand. Adv. Eng. Mats. 2011, 13, 1-2; 93–99.

DOI: https://doi.org/10.1002/adem.201000208

[3] Du Z, Chen J, Yan F, Xiao Y. Effects of simvastatin on bone healing around titanium implants in osteoporotic rats. Clin Oral Implants Res 2009, 20: 145-150.

DOI: https://doi.org/10.1111/j.1600-0501.2008.01630.x

[4] Green D, Walsh D, Mann S and Oreffo R. The Potential of Biomimesis in Bone Tissue Engineering: Lessons from the Design and Synthesis of Invertebrate Skeletons. Bone 30, 810-815 (2002).

DOI: https://doi.org/10.1016/s8756-3282(02)00727-5

[5] Junqueira JC, Mancini MN, Carvalho YR, Anbinder AL, Balducci I, Rocha RF. (2002). Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels. J Oral Sci. Dec; 44(3-4): 117-24.

DOI: https://doi.org/10.2334/josnusd.44.117

[6] Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK. (2011). Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species. Exp Mol Med. 43(11): 605-612.

DOI: https://doi.org/10.3858/emm.2011.43.11.067

[7] Otsuka M, Oshinbe A, LeGeros RZ, Tokudome Y, Ito A, Otsuka K, Higuchi WI, Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats, J. Pharm. Sci., 97 (1), 421-432 (2008).

DOI: https://doi.org/10.1002/jps.21131

[8] Skoglund B, Forslund C spenberg P. (2002). Simvastatin improves fracture healing in mice. J Bone Miner Res, 17: 2004-(2008).

DOI: https://doi.org/10.1359/jbmr.2002.17.11.2004

[9] Tokudome Y, Otsuka M, Ito A, LeGeros RZ, Long-Term Therapeutic Effect of Novel Calcium Phosphate-based Compounds Injected in Ovariectomized Rats, J. Biomed. Mat. Res. Part B: Applied Biomaterials, 90(1): 229-237 (2009).

DOI: https://doi.org/10.1002/jbm.b.31277

[10] Yamashita M, Otsuka F, Mukai T, Yamanaka R, Otani H, Matsumoto Y, Makamura E, Takano M, Sada KE, Makino H. (2010).