The Controlled Release of Simvastatin from Biomimetic Macrospheres
Simvastatin has been shown to succesfully stimulate bone regeneration and attention has being focussed on developing appropriate delivery carriers for its release. The challenge of deliverying therapeutic concentration of pharmaceutical compunds has being the centre of focus in drug delivery developments. This study examines the in-vivo effects of simvastatin released from β-TCP macrospheres derived from coral exoxskeletons. The results indicates that the controlled release of simvastatin can promote bone formation comparable with direct injection. Furthermore the results showed that the release of simvastatin delivery rates can be controlled by additional coating of an apatite coating. Analysis by CT scans, SEM, amount of new bone formed and mechanical strength tests, showed that by controlling the release of simvastatin bone formation can be stimulated to a therapeutic level.
Kunio Ishikawa and Yukihide Iwamoto
J. Chou, T. Ito, M. Otsuka, B. Ben-Nissan, B. Milthorpe, "The Controlled Release of Simvastatin from Biomimetic Macrospheres", Key Engineering Materials, Vols. 529-530, pp. 461-464, 2013