Fabrication of Bioactive Apatite Nuclei-Precipitated Titanium Alloys by Using Sandblasting


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Micropores were formed on the surface of Ti metal, Ti-15Mo-5Zr-3Al alloy, Ti-12Ta-9Nb-3V-6Zr-O alloy plate by doubled sandblasting process using silicon carbide particles with 14.0 μm for average particle size as first process, then using the particles with 3.0 μm for average particle size as second process. Apatite Nuclei (AN) were precipitated in the pores. By these treatments, bioactive AN-precipitated Ti alloys were fabricated. Bioactivity of the AN-precipitated Ti alloys was examined by soaking in SBF and it was observed that hydroxyapatite was induced on the surface of the Ti alloys within 1 d. High adhesive strength of hydroxyapatite layer was achieved due to a mechanical interlocking effect between hydroxyapatite formed in the micropores and the plate.



Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto




H. Mizuno et al., "Fabrication of Bioactive Apatite Nuclei-Precipitated Titanium Alloys by Using Sandblasting", Key Engineering Materials, Vols. 529-530, pp. 553-558, 2013

Online since:

November 2012




[1] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W, J. Biomed. Mater. Res. 24 (1990) 721-734.

DOI: https://doi.org/10.1002/jbm.820240607

[2] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity?, Biomaterials 27 (2006) 2907-2915.

DOI: https://doi.org/10.1016/j.biomaterials.2006.01.017

[3] H. Takadama, T. Kokubo, In vitro evaluation of bone bioactivity, in: T. Kokubo (Ed. ), Bioceramics and their clinical applications, Woodhead Publishing, Cambridge, 2008, pp.165-182.

DOI: https://doi.org/10.1533/9781845694227.1.165

[4] T. Yao, M. Hibino, S. Yamaguchi and H. Okada, PCT Patent PCT/JP2006/316054 (2006).

[5] T. Yao, T. Yabutsuka, Biomimetic fabrication of hydroxyapatite microcapsules by using apatite nuclei, in: A. Mukherjee (Ed. ), Biomimetics, Learning from Nature, Intech, Vukovar, 2010, pp.273-288.

DOI: https://doi.org/10.5772/8786

[6] T. Yao, M. Hibino and T. Yabutsuka, PCT Patent PCT/JP2007/062301 (2007), US 8178066 B2 (2012).

[7] T. Yabutsuka, M. Hibino, T. Yao, Development of bioactive titanium-apatite nuclei composite, Key Eng. Mater. 361-363 (2008) 709-712.

DOI: https://doi.org/10.4028/www.scientific.net/kem.361-363.709

[8] T. Yabutsuka, M. Hibino, T. Yao, K. Tanaka, M. Takemoto, M. Neo, T. Nakamura, Fabrication of bioactive apatite nuclei precipitated titanium by using electromagnetic induction heating, Bioceramics Development and Applications 1 (2010) D110122.

DOI: https://doi.org/10.4303/bda/d110122

[9] T. Yao, T. Yabutsuka, Japan Patent JP 2011-242912 (2011).

[10] T. Yabutsuka, H. Mizuno, T. Yao, Preparation of bioactive apatite nuclei-precipitated composites by using sandblasting process, Extended Abstracts of The 11th Asian BioCeramics Symposium (2011) 54-55.

DOI: https://doi.org/10.4028/www.scientific.net/kem.587.165

[11] W. Lacefield, Hydroxylapatite coatings, in: L. L. Hench, J. Wilson (Eds. ), An Introduction to Bioceramics, World Sci. Singapore, 1993, pp.223-238.