Investigation of Multilayered Protein Adsorption on Carbonate Apatite with a QCM Technique

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This study is concerned with multilayered protein adsorption on carbonate apatite (CAp) that is measured with a quartz crystal microbalance (QCM) technique. A carbonate apatite-deposited QCM sensor was prepared by electrophoretic deposition (EPD). On the CAp-deposited QCM sensor, fibrinogen adsorption followed by thrombin adsorption was investigated. The adsorption of fibrinogen on CAp led to a clear decrease in the resonance frequency of the sensor, which means that fibrinogen adsorbed on the CAp-deposited QCM sensor. The adsorbed amount of fibrinogen was larger on CAp than on a pristine sensor (Au). Although successive thrombin adsorption occurred on fibrinogen adlayers on both CAp and Au, the adsorbed amount and its conformation were different depending on the surface.

Info:

Periodical:

Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

74-77

DOI:

10.4028/www.scientific.net/KEM.529-530.74

Citation:

T. Yoshioka et al., "Investigation of Multilayered Protein Adsorption on Carbonate Apatite with a QCM Technique", Key Engineering Materials, Vols. 529-530, pp. 74-77, 2013

Online since:

November 2012

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$35.00

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