Enhanced Effects of New Bone Formation by an Electrically Polarized Hydroxyapatite Microgranule/Platelet-Rich Plasma Composite Gel

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The effects of electrically polarized HA microgranule/PRP compositeon new bone formation were examined. The composite gel was implanted into bone holes in rabbits. Histological examination was performed 3 and 6 weeks post-surgery. It was hypothesized that PRP alone could not induce new bone formation until 6 weeks after implantation. HA microgranules with or without electrical polarization/PRP composite, especially the former, activated osteogenic cells, resulting in enhanced bone formation. It was confirmed that electrical polarization treatment of HA microgranules can accelerate new bone formation and this effect is enhanced by forming a complex within PRP.

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Periodical:

Key Engineering Materials (Volumes 529-530)

Main Theme:

Edited by:

Kunio Ishikawa and Yukihide Iwamoto

Pages:

82-87

Citation:

S. Ohba et al., "Enhanced Effects of New Bone Formation by an Electrically Polarized Hydroxyapatite Microgranule/Platelet-Rich Plasma Composite Gel", Key Engineering Materials, Vols. 529-530, pp. 82-87, 2013

Online since:

November 2012

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$38.00

[1] Kiuru J, Viinikka L, Myllyla G, Personen K, Perheentupa J. Cytoskeletondependentrelease of human platelet epidermal growth factor. Life Sci 1991; 49: 1997–(2003).

DOI: https://doi.org/10.1016/0024-3205(91)90642-o

[2] Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 2004; 114: 1502–8.

DOI: https://doi.org/10.1097/01.prs.0000138251.07040.51

[3] Nakamura S, Takeda H, Yamashita K. Proton transport polarization and depolarization of hydroxyapatite ceramics. J Appl Phys 2001; 89: 5386-5392.

DOI: https://doi.org/10.1063/1.1357783

[4] Itoh S, Nakamura S, Nakamura M, Shinomiya K, Yamashita K. Enhanced Bone ingrowth into hydroxyapatite with interconnected pores by Electrical Polarization. Biomaterials 2006; 27: 5572-5579.

DOI: https://doi.org/10.1016/j.biomaterials.2006.07.007

[5] Hoogendoorn HA, Renooij W, Akkermans LMA, Visser DDS, Wittebol P. Long-term study of large ceramic implants in dog femora. Clin Orthop 1984; 187: 281–288.

DOI: https://doi.org/10.1097/00003086-198407000-00043

[6] Wang W, Itoh S, Yamamoto N, Okawa A, Nagai A, Yamashita A. Electrical polarization of b-tricalcium phosphate ceramics. J Am Ceram Soc 2010; 93: 2175-2177.

DOI: https://doi.org/10.1111/j.1551-2916.2010.03710.x

[7] Yamashita K, Kitagawa K, Umegaki T. Thermal instability and proton conductivity of ceramic hydroxyapatite at high temperatures. J Am Ceram Soc 1995; 78: 1191-1197.

DOI: https://doi.org/10.1111/j.1151-2916.1995.tb08468.x

[8] Nakamura M, Nagai A, Okura T, Sekijima Y, Hentunen T, Yamashita K. Enhanced osteoblastic adhesion through improved wettability on polarized hydroxyapatite. J Ceram Soc of Jpn 2010; 118: 474–8.

DOI: https://doi.org/10.2109/jcersj2.118.474