Enhanced Effects of New Bone Formation by an Electrically Polarized Hydroxyapatite Microgranule/Platelet-Rich Plasma Composite Gel
The effects of electrically polarized HA microgranule/PRP compositeon new bone formation were examined. The composite gel was implanted into bone holes in rabbits. Histological examination was performed 3 and 6 weeks post-surgery. It was hypothesized that PRP alone could not induce new bone formation until 6 weeks after implantation. HA microgranules with or without electrical polarization/PRP composite, especially the former, activated osteogenic cells, resulting in enhanced bone formation. It was confirmed that electrical polarization treatment of HA microgranules can accelerate new bone formation and this effect is enhanced by forming a complex within PRP.
Kunio Ishikawa and Yukihide Iwamoto
S. Ohba et al., "Enhanced Effects of New Bone Formation by an Electrically Polarized Hydroxyapatite Microgranule/Platelet-Rich Plasma Composite Gel", Key Engineering Materials, Vols. 529-530, pp. 82-87, 2013