Cytotoxicity Effects of CdTe Quantum Dots on Human Lung Cancer A549 Cells

Abstract:

Article Preview

In order to explore the possibility of the novel CdTe QDs (cadmium telluride quantum dots) as future delivery carrier material, the cytotoxicity effects of CdTe QDs was evaluated in human lung adenocarcinoma A549 cells and with normal HELF cells as control. The cell proliferation fraction was analyzed under the treatments of CdTe QDs by MTT and RTCA. The results showed that CdTe QDs present minor cytotoxicity on the proliferation of these two cell lines at the lower concentrations less than 0.18µmol/L within 72 h, and show toxicity effects under high concentrations. Besides, combination of CdTe QDs at lower concentration (<0.18µmol/L) together with DOX can enhance the killing fraction on A549 more than that of DOX alone, which indicated the drug carrier potential of CdTe QDs, and provided the important basic experiments for further development.

Info:

Periodical:

Key Engineering Materials (Volumes 531-532)

Edited by:

Chunliang Zhang and Liangchi Zhang

Pages:

504-507

Citation:

S. Han and Q. N. Li, "Cytotoxicity Effects of CdTe Quantum Dots on Human Lung Cancer A549 Cells", Key Engineering Materials, Vols. 531-532, pp. 504-507, 2013

Online since:

December 2012

Export:

Price:

$38.00

[1] Solly K, Wang X, Xu X, Strulovici B, Zheng W: Assay Drug Dev Technol. Vol. 2(2004), pp.363-372.

[2] Jokerst JV, Raamanathan A, Christodoulides N: Biosens Bioelectron. Vol. 24(2009), pp.3622-3629.

[3] Maksym V. Yezhelyev, Ruth M. O'Regan, Nie Shuming: J American Chem Soc. Vol. 130(2008), p.9006–9012.

[4] Song E Q, Zhang Z L, Luo Q Y: Clin Chem. Vol. 55(2009), pp.955-963.

[5] Zhang G, Shi L, Selke M: Nanoscal Res Lett. Vol. 6(2011), p.418.

[6] Andrew M. Smith, Aaron M. Mohs: Adv Drug Del Rev. Vol. 60(2008), p.1226–1240.

[7] Liu L, Su X, Ralph P. Mason: J Biomed Nanotech. Vol. 4(2008), p.524–528.

[8] Choi AO, Cho SJ, Desbarats J: J Nanobiotech. Vol. 5(2007), pp.1-13.

[9] Ambrosone A, Mattera L, Marchesano V: Biomaterials. Vol. 33 (2012), p.1991-(2000).

[10] Zhang H, Cui Z C, Wang Y, Zhang K, Ji X, Lu C L, Yang B, Gao M Y: AdV. Mater. Vol. 15(2003), pp.777-783.

Fetching data from Crossref.
This may take some time to load.