Gelatin Coated 45S5 Bioglass®-Derived Scaffolds for Bone Tissue Engineering
Highly porous 45S5 Bioglass® scaffolds were fabricated by the foam replica method and successfully coated with a well attached gelatin layer by dipping and pipetting methods. Depending on macropore size of the scaffold and gelatin concentration, mechanically enhanced scaffolds with improved compressive strength in comparison to uncoated scaffolds could be obtained while preserving the high and interconnected porosity that is required for bone in-growth. Moreover, the scaffolds bioactivity by immersion in simulated body fluid (SBF) was investigated showing that gelatin coating preserves the intrinsic bioactivity of the Bioglass® scaffold. It was also shown that the gelatin layer can be loaded with tetracycline hydrochloride for developing scaffolds with drug delivery capability.
Alessandra Bianco, Ilaria Cacciotti and Ilaria Cappelloni
A. L. Metze et al., "Gelatin Coated 45S5 Bioglass®-Derived Scaffolds for Bone Tissue Engineering", Key Engineering Materials, Vol. 541, pp. 31-39, 2013