In Vitro Response and Adhesive Strength of Titanium and Hydroxyapatite Bilayer-Films on Polyetheretherketone Substrate
In order to impart both osseointegration and osteoconduction characteristics onto extruded pure polyetheretherketone (PEEK) for use as an artificial bone material, the surface of the PEEK was sputter-coated with a thin bilayer-film consisting of a commercially pure titanium (Ti) layer with a thickness of 90 nm and a hydroxyapatite layer with a thickness of 200 nm derived from simulated body fluid (SBF-HA). A specimen of PEEK coated only with Ti was used in peeling tests to determine the adhesive strength of the interface between the two materials, which was found to be 2.55 ± 0.45 MPa. Tensile tests were also carried out, and it was found that no exfoliation of the Ti film occurred until an ultimate strain of 129% was reached. In a cell culture test using mouse osteoblast on the bilayer-coated PEEK, cell proliferation following 168 h of culturing was 1.3 times higher on the SBF-HA than on synthetic hydroxyapatite, and 2.4 times higher than that on the Ti-coated PEEK. In addition, the proliferation on the Ti-coated PEEK was 2.1 times higher than that on uncoated PEEK.
Iulian Antoniac, Cosmin Mihai Cotrut and Aurora Antoniac
T. Hayami and M. Kusunoki, "In Vitro Response and Adhesive Strength of Titanium and Hydroxyapatite Bilayer-Films on Polyetheretherketone Substrate", Key Engineering Materials, Vol. 583, pp. 51-55, 2014