In Vitro Evaluation of the Cytotoxicity of Some New Titanium Alloys


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Titanium alloys are widely used in medical applications, due to their good mechanical properties, high corrosion resistance and biocompatibility. The aim of this paper was to investigate the cytotoxicity of novel titanium alloys: Ti21Nb6Zr15Ta, Ti25Nb10Zr8Ta, Ti17Nb5Zr5Al, Ti7Nb7Zr2Al with fibroblast-like cells derived from human osteosarcoma cell line (HOS). The results were compared with that of conventional biomedical alloys, like Ti6Al7Nb and Ti6Al4V. In vitro citotoxicity of titanium alloys was evaluated by fluorescence microscopy and MTT colorimetric assay. The results showed that the materials analyzed had no cytotoxic effects on HOS fibroblast-like cells, permitting their attachment and proliferation. Also the new titanium alloys present a higher cell viability than that of the conventional alloys. As a consequence, the TiNbZrTa and TiNbZrAl alloys can be considered as potential candidates for biomedical applications.



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Edited by:

Iulian Antoniac, Simona Cavalu and Teodor Traistaru






A. C. Bărbînţă et al., "In Vitro Evaluation of the Cytotoxicity of Some New Titanium Alloys", Key Engineering Materials, Vol. 587, pp. 303-308, 2014

Online since:

November 2013




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