Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules


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Restoring alveolar bone following tooth extraction or pathological diseases is important, and recent efforts have been made to overcome the use of autografts during dental implantation. Although micro-macroporous biphasic calcium phosphate (MBCPTM) has performed well in orthopedic procedures, few studies have investigated its use in dentistry. Here, we report a greater than eight-year clinical follow-up of bone regeneration using MBCPTM after sinus grafting. MBCPTM technology is a unique mixture of hydroxyapatite and β-tricalcium phosphate, which displays both macroporosity and microporosity. A total of 25 patients (33 implantation sites) were evaluated by X-rays, and their pre-operative and immediate post-operative bone heights were measured. After approximately six months, dental implantation was performed. Subsequently, X rays were performed each year, and bone height was measured. In all cases, radio-opacity of the implantation area decreased with time, indicating resorption and bone ingrowth at the expense of the MBCPTM material. After one year, the implantation area had the appearance of physiological bone and <11% of height loss was observed. Strikingly, the newly formed bone was preserved after 78 years of follow-up, with only <14% of height loss recorded. We demonstrate that sinus grafting followed by dental implantation with a resorbable and bioactive synthetic bone graft material (MBCPTM technology) safely and efficiently supports dental implantation.



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Edited by:

Iulian Antoniac, Simona Cavalu and Teodor Traistaru




K. C. Seong et al., "Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules", Key Engineering Materials, Vol. 587, pp. 321-324, 2014

Online since:

November 2013




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