Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules


Article Preview

Restoring alveolar bone following tooth extraction or pathological diseases is important, and recent efforts have been made to overcome the use of autografts during dental implantation. Although micro-macroporous biphasic calcium phosphate (MBCPTM) has performed well in orthopedic procedures, few studies have investigated its use in dentistry. Here, we report a greater than eight-year clinical follow-up of bone regeneration using MBCPTM after sinus grafting. MBCPTM technology is a unique mixture of hydroxyapatite and β-tricalcium phosphate, which displays both macroporosity and microporosity. A total of 25 patients (33 implantation sites) were evaluated by X-rays, and their pre-operative and immediate post-operative bone heights were measured. After approximately six months, dental implantation was performed. Subsequently, X rays were performed each year, and bone height was measured. In all cases, radio-opacity of the implantation area decreased with time, indicating resorption and bone ingrowth at the expense of the MBCPTM material. After one year, the implantation area had the appearance of physiological bone and <11% of height loss was observed. Strikingly, the newly formed bone was preserved after 78 years of follow-up, with only <14% of height loss recorded. We demonstrate that sinus grafting followed by dental implantation with a resorbable and bioactive synthetic bone graft material (MBCPTM technology) safely and efficiently supports dental implantation.



Main Theme:

Edited by:

Iulian Antoniac, Simona Cavalu and Teodor Traistaru




K. C. Seong et al., "Eight-Year Clinical Follow-Up of Sinus Grafts with Micro-Macroporous Biphasic Calcium Phosphate Granules", Key Engineering Materials, Vol. 587, pp. 321-324, 2014

Online since:

November 2013




[1] Dorozhkin S.V. (2013). Calcium orthophosphates in dentistry. J Mater Sci Mater Med 24: 1335-1363.

[2] LeGeros R.Z. (1991). Calcium phosphate in oral biology and medicine. Basel; Karger: p.211.

[3] Daculsi G., Laboux O., Malard O., Weiss P.J. (2003). Current state of the art of biphasic calcium phosphate bioceramics. J Mater Sci Mater Med 14(3): 195-200.

[4] Daculsi G., Passuti N., Martin S., Deudon C., LeGeros R.Z. (1990). Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study. J Biomed Mater Res 24(3): 379-396.

DOI: https://doi.org/10.1002/jbm.820240309

[5] Gouin, F., et al. (1995). Comblement osseux par céramique phosphocalcique biphasée macroporeuse: a propos de 23 cas. Rev Chir Orthop 81: 59-65.

[6] Ransford A.O., Morley T., Edgar M.A., et al. (1998). J Bone Joint Surg Br 80(1): 13-18.

[7] Cavagna, R., Daculsi, G., Bouler, J.M. (1999). Macroporous biphasic calcium phosphate: a prospective study of 106 cases in lumbar spine fusion. Long Term Effects Med Impl 9: 403-412.

[8] Nery E.B., Eslami A., Van Swol S.R. (1990). Biphasic calcium phosphate ceramic combined with fibrillar collagen with and without citric acid conditioning in the treatment of periodontal osseous defects. J Periodontol 61(3): 166-172.

DOI: https://doi.org/10.1902/jop.1990.61.3.166

[9] Piatelli A., Scarano A., Mangano C. (1996). Clinical and histologic aspects of biphasic calcium phosphate ceramic (BCP) used in connection with implant placement. Biomaterials 17(18): 1767-1770.

DOI: https://doi.org/10.1016/0142-9612(95)00342-8

[10] Block M.S., Kent J.N. (1986). A comparison of particulate and solid root forms of hydroxylapatite in dog extraction sites. J Oral Maxillofac Surg 44(2): 89-93.

[11] Tiwari S., Nandhal B. (2012). Role of synthetic hydroxyapatite in dentistry. Saarbrucken; Lap Lambert Academic Publishing: p.90.

Fetching data from Crossref.
This may take some time to load.