Bioceramic Drug Delivery System for Cancer Treatment and Regenerative Medicine

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Silica-calcium-phosphate composite (SCPC) is a drug delivery platform that has successfully demonstrated the ability to bind and release several therapeutics including antibiotics, peptides, anticancer drugs, and growth factors. It has successfully demonstrated a unique capacity for bone regeneration. The present studies address the effect of the phosphate and silicate functional groups on drug binding and controlled release kinetics of Cisplatin (Cis). Moreover, the roles of ceramic composition and resorbability on rhBMP2 release kinetics and bone regeneration in a critical size calvarial defect in rabbit is presented.

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Edited by:

Ika Dewi Ana, Kuwat Triyana

Pages:

245-249

Citation:

A. El-Ghannam, "Bioceramic Drug Delivery System for Cancer Treatment and Regenerative Medicine", Key Engineering Materials, Vol. 696, pp. 245-249, 2016

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May 2016

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$38.00

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[1] Rania Fahmy, Naguiba Mahmoud, Samia Soliman and Samir R. Nouh, Larry Cunningham, Ahmed El-Ghannam, Acceleration of Alveolar Ridge Augmentation Using a Low Dose of rhBMP2 Loaded on a Resorbable Bioactive Ceramic, Journal of Oral and Maxillofacial Surgery, Published on line (2015).

DOI: https://doi.org/10.1016/j.joms.2015.07.004

[2] Ahmed El-Ghannam, Advanced Bioceramic Composite for Bone Tissue Engineering: Design Principles and Structure-Bioactivity Relationship, Journal of Biomedical Materials Research, 1; 69A(3): 490-501 (2004).

DOI: https://doi.org/10.1002/jbm.a.30022

[3] Pacheco H, Vedantham K, Aniket, Young A, Marriott I, El-Ghannam A., Tissue engineering scaffold for sequential release of vancomycin and rh-BMP2 to treat bone infections,. J Biomed Mater Res A; 102(12): 4213-23 (2014).

DOI: https://doi.org/10.1002/jbm.a.35092

[4] Ahmed El-Ghannam, Larry Cunningham, Dean White, Amanda Hart, Mechanical Properties And Cytotoxicity Of A Resorbable Bioactive Implant Prepared By Rapid Prototyping Technique, Journal of Biomedical Materials Research-Part A, Volume 101, 10, 2851–2861 (2013).

DOI: https://doi.org/10.1002/jbm.a.34585

[5] Swet J H., Pacheco H., David A. Iannitti D., El-Ghanam A., McKillop I H. A Silica-Calcium-Phosphate Nanocomposite (SCPC) Drug Delivery System for Treatment of Hepatocellular Carcinoma (HCC): In Vivo Study. J Biomed Mater Res Part B, Vol 102, 1, 190–202 (2014).

DOI: https://doi.org/10.1002/jbm.b.32995