Preparation of Brushite Bone Cement with a Drug Containing β-Tricalcium Phosphate Granules

Abstract:

Article Preview

Brushite bone cement containing a drug was prepared using the dense granular β-tricalciump phospahte (β-TCP) as a starting material. The setting reaction was not significantly affected by loading antibiotics within the granules. Heat treatment of the granule at elevated temperature resulted in the suppression of temperature increase during setting, which provided benefits in drug loading. The amount of gentamicin sulfate infiltrated in the β-TCP granules was determined by thermogravimetric analysis and was found to be meaningful considering the MIC of microorganisms.

Info:

Periodical:

Main Theme:

Edited by:

Ahmed El-Ghannam

Pages:

143-146

Citation:

I. C. Lee et al., "Preparation of Brushite Bone Cement with a Drug Containing β-Tricalcium Phosphate Granules", Key Engineering Materials, Vol. 720, pp. 143-146, 2017

Online since:

November 2016

Export:

Price:

$41.00

* - Corresponding Author

[1] M. Bohner, J. Lemaitre, P. Van Landuyt, P.Y. Zambelli, H.P. Merkle, B. Gander, Gentamicin-Loaded Hydraulic Calcium Phosphate Bone Cement as Antibiotic Delivery System, J. Pharm. Sci. 86 (1997) 565-72.

DOI: https://doi.org/10.1021/js960405a

[2] M. Bohner, J. Lemaitre, H.P. Merkle, B. Gander, Control of Gentamicin Release from a Calcium Phosphate Cement by Admixed Poly(acrylic acid), J. Pharm. Sci. 89 (2000) 1262-70.

DOI: https://doi.org/10.1002/1520-6017(200010)89:10<1262::aid-jps4>3.3.co;2-z

[3] S.A. Lee, T.J. Chung, K.S. Oh, Effect of Storage Conditions on the Setting Properties of Brushite Bone Cement Containing Granular β-Tricalcium Phosphate, J. Kor. Ceram. Soc. 45 (2008) 624-29.

[4] S.V. Dorozhkin, Calcium Orthophosphates, J. Mater. Sci. 42 (2007) 1061-95.

[5] J.C. Elliott, Structure and Chemistry of the Apatites and Other Calcium Orthophosphates, Elsevier, Amsterdam, London, New York, Tokyo, 1994, pp.6-11.

[6] J. Morant, H. Ruppaner, In Arzneimittel-Kompendium der Schweiz; Basler Zeitung: Basel, 1996, p.834.