Preparation of Brushite Bone Cement with a Drug Containing β-Tricalcium Phosphate Granules
Brushite bone cement containing a drug was prepared using the dense granular β-tricalciump phospahte (β-TCP) as a starting material. The setting reaction was not significantly affected by loading antibiotics within the granules. Heat treatment of the granule at elevated temperature resulted in the suppression of temperature increase during setting, which provided benefits in drug loading. The amount of gentamicin sulfate infiltrated in the β-TCP granules was determined by thermogravimetric analysis and was found to be meaningful considering the MIC of microorganisms.
I. C. Lee et al., "Preparation of Brushite Bone Cement with a Drug Containing β-Tricalcium Phosphate Granules", Key Engineering Materials, Vol. 720, pp. 143-146, 2017