Characterization of Hydrothermal Processing Influence on Strontium Substituted Apatite by Investigating Stable Oxygen Isotope Ratio and Antibacterial Activity of Obtained Peroxyapatite
Synthetic hydroxyapatite (HAp) has weak antibacterial and mechanical properties. The antibacterial activity of HAp can be enhanced by strontium cation substitution and incorporation of peroxide ion via hydrothermal processing at 100 °C and 150 °C temperature using 50% H2O2 solution. The starting reagents and products of HAp processing were analyzed by thermal conversion elemental analyser – isotopic ratio mass spectrometer in order to determine the δ18O values. Using different host materials it could be possible to determine differences of δ18O values between untreated and hydrothermally treated HAp samples. The enhanced antibacterial properties of processed HAp samples were investigated using Pseudomonas aeruginosa and Staphylococcus aureus. Hydrothermal processing by H2O2 solutions provides additional antibacterial activity and peroxide content of hydrothermally treated samples affect δ18O values.
V. Valkovska et al., "Characterization of Hydrothermal Processing Influence on Strontium Substituted Apatite by Investigating Stable Oxygen Isotope Ratio and Antibacterial Activity of Obtained Peroxyapatite", Key Engineering Materials, Vol. 762, pp. 14-18, 2018