A Clinical Trial for Bone Void Filler Made from Derived Hydroxyapatite from Cockle Shell Mixed with Rice Starch


Article Preview

In this study, we have demonstrated that bone void filler made from hydroxyapatite (HAP) which derived from cockle shell. This sample mixed with rice starch and can be used to augment new bone growth in the empty space defects of damaged hard tissue, such as bone, spine and skull. The chemical compositions of HAP get along with standard specification for composition of ceramic HAP for surgical implants (ASTM International: F1185-88). The starch content was in the safety range of classical cell culture formulation. 60 patients were treated with this bone void filler show successfully healing and recovery, after 6 months period of follow up, confirmed safety and efficacy of the medical device properties. It should be an alternative choice for bone substitute in the future.



Edited by:

Marina Polyakova




S. Punyanitya et al., "A Clinical Trial for Bone Void Filler Made from Derived Hydroxyapatite from Cockle Shell Mixed with Rice Starch", Key Engineering Materials, Vol. 779, pp. 50-53, 2018

Online since:

September 2018




* - Corresponding Author

[1] Information on https://en.wikipedia.org/wiki/Bone_healing.15/3/(2018).

[2] R. X. Sun, Y. Lv, Y. R. Niu, X.H. Zhao, D.S. CaO, J. Tang, X.C. Sun and K.Z. Chen: Ceram Inter Vol. 43 (2017), p.16792 – 16798.

[3] T. Hemamalini, V. Rengaswami and G. Dev: Int J of Biol Macromol. Vol. 106 (2018), p.712 – 718.

[4] Information on https://en.wikipedia.org/wiki/Glucose.16/3/(2018).

[5] Information on http://apps.who.int/iris/bitstream/10665/93142/1/EML_18_eng.pdf?ua=1.

[6] D.H. Wasserman: Am J Physiol Endcrinol Metab. Vol. 296 (2009), p. E11- E21.

[7] W. Niu, Y. Wang, Y. Liu, B. Zhang, M. Liu, Y. Luo, P. Zhao, Y Zhang, H. Wu, L. Ma and Z. Li: Acta Histochem. Vol. 119 (2017), p.257 – 263.

[8] G. Matsumoto, Y. Sugita, K. Kubo, W. Yoshida, Y. Ikada, S. Sobajima, M. Neo, H. Maeda and Y. Kinoshita: J Biomater Appl. Vol. 28 (2014), p.1316 – 1324.

DOI: https://doi.org/10.1177/0885328213507299

[9] Z. Shen, T. Yu and J. Ye: Mater Sci Eng C. Mater Biol Appl. Vol. 42 (2014), p.303 – 311.

[10] F.J. Murat, M.H. Ereth, Y. Dong, M.P. Piedra and M.T. gettman: J Urol. Vol. 172 (2004), p.1119 – 1122.

[11] M.R. Humphreys, E.P. Castle, P.E. Andrews, M.T. Gettman and M.H. Ereth: Am J Surg. Vol. 195 (2008), p.99 – 103.

[12] Information on https://www.sigmaaldrich.com/life-science/cell-culture/learning-center/media- expert/glucose.html. 16/6/(2018).

[13] H.F. Bunn and P.J. Higgins: Science Vol. 213 (1981), p.222–224.

[14] K. Tontisirin, in: FAO Food and Nutrition Paper 77, Chapter, 3, Calculation of the Energy Content of Foods – Energy Conversion Factors, organization, food and agiculture organization of the united nations, Rome (2003).

[15] Standard Specification for Composition of Ceramic Hydroxylapatite for Surgical Implants. ASTM Designation: F 1185-88 (Reapproved 1993).

[16] R. Koonawoot, S. Thiansem, S. Punyanitya, A. Raksujarit, S. Laosatirawong and W. Pompimon: Adv Mat Res. Vol. 311-313 (2011), pp.1621-1624.

DOI: https://doi.org/10.4028/www.scientific.net/amr.311-313.1621

[17] S. Punyanitya, R. Koonawoot, A. Rucksanti, S. Thiensem, A. Raksujarit and W. Sontichai: Key Eng Mater. Vol. 744 (2017), pp.480-484.

DOI: https://doi.org/10.4028/www.scientific.net/kem.744.480

[18] S. Punyanitya, W. Punyanitya, S. Thiansem and R. Koonawoot: submitted to Journal of Key Engineering Materials (2018).