Compare of Electrospinning PLA and PLA/β-TCP Scaffold in Vitro


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In recent years, electrospinning process is gradually applied in producing tissue-engineering scaffold. In this study, we chose polylacticacid(PLA) and β-tertiary calcium phosphate(β-TCP) as raw materials to fabricate PLA/β-TCP biodegradable composite scaffold by electrospinning process. The characteristics of the scaffold and effect of the scaffolds to cell proliferation and cell adhesion was studied. Compare with pure PLA scaffold, blendingβ-TCP in the spinning process of the scaffold could improve the properties of the scaffold, especially the hydrophilicity and the proliferation and adhesion of cells, this means that the material is more potential to be used as tissue engineering scaffolds.



Materials Science Forum (Volumes 475-479)

Main Theme:

Edited by:

Z.Y. Zhong, H. Saka, T.H. Kim, E.A. Holm, Y.F. Han and X.S. Xie






H. S. Fan et al., "Compare of Electrospinning PLA and PLA/β-TCP Scaffold in Vitro", Materials Science Forum, Vols. 475-479, pp. 2379-2382, 2005

Online since:

January 2005




[1] Robert Lanza, Robert langer, William Chick Principles of tissue engineering. 1997 R.G. Landes Company.

[2] Wan-Ju Li, Cato T. Laurencin, Edward J. Caterson, Rocky S. Tuan, Frank K. Ko Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J Biomed Mater Res 60: 613-621, (2002).

DOI: 10.1002/jbm.10167

[3] H. Yoshimoto, Y.M. Shin, H. Yerai, J.P. Vacanti A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24(2003) 2077-(2082).

DOI: 10.1016/s0142-9612(02)00635-x

[4] Chirstopher J. Buchko, Loui C. Chen, Yu shen, David C. Martin Processing and microstructural characterization of porous biocompatible protein polymer thin films. Polymer 40(1999)7397-7407.

DOI: 10.1016/s0032-3861(98)00866-0

[5] A. Buer, S.C. Ugbolue, S.B. Warner Electrospinning and Properties of Some Nanofibers. Textile Res. J. 71(4), 323-328(2001).

DOI: 10.1177/004051750107100408

[6] Zheng-Ming Hunag, Y.Z. Zhang, M. Kotaki, S. Ramakrishna A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Composites science and Technology 63(2003) 2223-2253.

DOI: 10.1016/s0266-3538(03)00178-7

[7] Itala Ai, Ylanen Ho, Ekholm C, Karlsson KH, Aro HT Pore diameter of more than 100μm is not requisite for bone ingrowth in rabbits. J Biomed Mater Res, Appl Biomater 2001; 58: 6790-683.

DOI: 10.1002/jbm.1069

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