Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins


Article Preview

The aim of this work was the exploration of a potential biocompatible membrane prepared from a modified polyetheretherketone (PEEK-WC). The physico-chemical properties of PEEK-WC were characterised by Differential Scanning Calorimetry and FT-Infrared Spectroscopy. The surface affinity of this membrane to human plasma and proteins such as albumin, fibrinogen and immunoglobulins G was evaluated and compared with that of commercial membranes. The wettability of all investigated membranes was established by water contact angle measurements. PEEK-WC membranes exhibited moderate wettability and low protein adsorption, differently from other commercial membranes such as cellulose acetate membrane. A preferential adsorption of hydrophilic proteins as albumin on the membrane surfaces was observed. Human plasma adsorption on membranes followed the same trend as individual protein solutions.



Materials Science Forum (Volumes 480-481)

Edited by:

A. Méndez-Vilas




L. De Bartolo et al., "Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins", Materials Science Forum, Vols. 480-481, pp. 257-268, 2005

Online since:

March 2005




[1] L. De Bartolo and E. Drioli: Biomedical and Health Research: New Biomedical Materials - Basic and Applied Studies (P.I. Haris and D. Chapman, eds., IOS Press, Amsterdam/Berlin/Tokjo/Washington, 1998).

[2] L. De Bartolo, G. Jarosch-Von Schweder, A. Haverich and A. Bader: Biotechnol. Progress Vol. 16 (2000), p.102.


[3] J.M. Courtney and C.D. Forbes: Br. Med. Bull. Vol. 4 (1994), p.966.

[4] K.A. Mowery, M.H. Schoenfish, J.E. Saavedra, L.K. Keefer and M.E. Meyerhoff: Biomaterials Vol. 21 (2000), p.9.

[5] M. Shen, L. Martinson, M.S. Wagner, D.G. Castner, B.D. Ratner and T.A. Horbett: J. Biomater. Sci. Polym. Ed. Vol. 13 (2002), p.367.

[6] T. Matsuda and S. Ito: Biomaterials Vol. 15 (1994), p.417.

[7] J. Y. HO, T. Matsuura, J. P. Santerre: J. Biomater. Sci. Polymer Edn. Vol. 11(2000), p.1085.

[8] K. Kimmerle and H. Strathmann: Desalination Vol. 79 (1990), p.283.

[9] A. Gugliuzza, G. Clarizia, G. Golemme and E. Drioli: Eur. Pol. J. Vol. 38 (2002), p.235.

[10] L. De Bartolo, S. Morelli, M. Rende, A. Gordano, E. Drioli: Biomaterials Vol. 25 (2004), p.3621.


[11] K.J. Liu, H.C. Zhang and T.L. Chen, Chin. Pat. CN 85, 101, 721, (1987).

[12] H.C. Zhang, T.L. Chen and Y.G. Yuan, Chin. Pat. CN 85, 108, 751, (1987).

[13] M. Oldani and G. Schock: J. Membrane Sci. Vol. 43 (1989), p.243.

[14] R.M. Silverstein, G.C. Bassler and T.C. Morril: Spectrometric identification of organic compounds, 5th ed. (Wiley, New York 1991).

[15] Surface Texture, American National Standard ANSI/ASME B46. 1, (American Society of Mechanical Engineers, New York, 1985).

[16] L. De Bartolo, S. Morelli, A. Bader and E. Drioli: J. Mater. Sci. -Mater. M. Vol. 12 (2001), p.959.

[17] L. De Bartolo, S. Morelli, A. Bader and E. Drioli: Biomaterials Vol. 23 (2002), p.2485.

[18] L. De Bartolo, A. Gugliuzza, S. Morelli, B. Cirillo, A. Gordano, E. Drioli: In press J. Mater. Sci. -Mater. M.

[19] C.J. van Oss: Interfacial Forces in Aqueous Media (Marcel Dekker, New York, 1994).

[20] B. Jansen and G. Ellinghorst: J. Biomed. Mater. Res. Vol. 18 (1984), p.655.

[21] J.H. Lee and H.B. Lee: J. Biomed. Mater. Res. Vol. 41(1998), p.304.

[22] L. De Bartolo, A. Gugliuzza, B. Cirillo, S. Morelli and E. Drioli: Mater. Res. Soc. Symp. Proc. Vol. 752 (2003), p.291.