Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins
The aim of this work was the exploration of a potential biocompatible membrane prepared from a modified polyetheretherketone (PEEK-WC). The physico-chemical properties of PEEK-WC were characterised by Differential Scanning Calorimetry and FT-Infrared Spectroscopy. The surface affinity of this membrane to human plasma and proteins such as albumin, fibrinogen and immunoglobulins G was evaluated and compared with that of commercial membranes. The wettability of all investigated membranes was established by water contact angle measurements. PEEK-WC membranes exhibited moderate wettability and low protein adsorption, differently from other commercial membranes such as cellulose acetate membrane. A preferential adsorption of hydrophilic proteins as albumin on the membrane surfaces was observed. Human plasma adsorption on membranes followed the same trend as individual protein solutions.
L. De Bartolo et al., "Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins", Materials Science Forum, Vols. 480-481, pp. 257-268, 2005