Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins

Abstract:

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The aim of this work was the exploration of a potential biocompatible membrane prepared from a modified polyetheretherketone (PEEK-WC). The physico-chemical properties of PEEK-WC were characterised by Differential Scanning Calorimetry and FT-Infrared Spectroscopy. The surface affinity of this membrane to human plasma and proteins such as albumin, fibrinogen and immunoglobulins G was evaluated and compared with that of commercial membranes. The wettability of all investigated membranes was established by water contact angle measurements. PEEK-WC membranes exhibited moderate wettability and low protein adsorption, differently from other commercial membranes such as cellulose acetate membrane. A preferential adsorption of hydrophilic proteins as albumin on the membrane surfaces was observed. Human plasma adsorption on membranes followed the same trend as individual protein solutions.

Info:

Periodical:

Materials Science Forum (Volumes 480-481)

Edited by:

A. Méndez-Vilas

Pages:

257-268

DOI:

10.4028/www.scientific.net/MSF.480-481.257

Citation:

L. De Bartolo et al., "Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins", Materials Science Forum, Vols. 480-481, pp. 257-268, 2005

Online since:

March 2005

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$35.00

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