Starting powder mixtures of ZnO and TiO2, at the molar ratio that is in accordance with the stoichiometry of zinc titanate Zn2TiO4, were mechanically activated using a planetary ball mill in different time intervals from 0 to 90 minutes. X-ray diffraction analysis, scanning electron microscopy and non-isothermal dilatometric measurements were performed in order to investigate zinc titanate formation. Processes occurring during mechanical activation led to the formation of a specific structure of obtained powders that promoted and accelerated solid-state reactions and densification during sintering. The main conclusion based on analysis is that mechanical activation enables better compaction of activated powders, i.e. possibility of achieving higher densities of green bodies without binders, but first of all that Zn2TiO4 ceramics can be obtained by mechanical activation after a certain time with appropriate thermal treatment, i.e. heating rate and sintering time, at temperatures lower than those when non-activated mixtures were used.